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http://acervodigital.unesp.br/handle/11449/70008- Title:
- Vernonia polyanthes as a new source of antiulcer drugs
- Universidade Estadual de Campinas (UNICAMP)
- Universidade Estadual Paulista (UNESP)
- 0367-326X
- Methanolic (VPME) and chloroformic (VPCL) extracts, obtained from the aerial parts of Vernonia polyanthes, were investigated for its antiulcerogenic properties. Administration of VPME (250 mg/kg) and VPCL (50 mg/kg) significantly inhibited the gastric mucosa damage (64% and 90%, respectively) caused by absolute ethanol (p.o.). Otherwise, in NSAID-induced gastric damage, their gastroprotective effects have decreased. Since the VPCL extract resulted to be more effective than the VPME we focused our efforts over VPCL action mechanism of action. © 2007 Elsevier B.V. All rights reserved.
- 1-Dec-2007
- Fitoterapia, v. 78, n. 7-8, p. 545-551, 2007.
- 545-551
- Action mechanisms
- Antiulcerogenic activity
- Vernonia polyanthes
- alcohol
- antiulcer agent
- carbenoxolone
- cimetidine
- lansoprazole
- n ethylmaleimide
- n(g) nitroarginine methyl ester
- nonsteroid antiinflammatory agent
- piroxicam
- plant extract
- unclassified drug
- vernonia polyanthes chloroformic extract
- Vernonia polyanthes extract
- vernonia polyanthes methanolic extract
- animal experiment
- animal model
- drug inhibition
- drug mechanism
- male
- medicinal plant
- mouse
- nonhuman
- priority journal
- rat
- stomach mucosa lesion
- vernonia polyanthes
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
- Anti-Ulcer Agents
- Dose-Response Relationship, Drug
- Ethanol
- Male
- Phytotherapy
- Plant Components, Aerial
- Plant Extracts
- Rats
- Rats, Wistar
- Stomach Ulcer
- Vernonia
- http://dx.doi.org/10.1016/j.fitote.2007.07.003
- Acesso restrito
- outro
- http://repositorio.unesp.br/handle/11449/70008
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