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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/73176
Title: 
The expression of aquaporins 1 and 9 in adult rat epididymis is perturbed by chronic exposure to ethanol
Author(s): 
Institution: 
  • Universidade Estadual Paulista (UNESP)
  • FURB - Universidade Regional de Blumenau
  • Universidade Federal de São Carlos (UFSCar)
ISSN: 
  • 0040-8166
  • 1532-3072
Abstract: 
Aquaporins (AQPs), notably AQP-1 and AQP-9, may contribute to reabsorption of fluid and solute across the epididymis. Ethanol is related to be a toxicant affecting directly or indirectly the epididymis and the sperm motility. This study examined the expression of AQP-1 and AQP-9 in adult epididymis of the UChA and UChB 10% (v/v) ethanol-preferring rats, focusing the ethanol-induced hormonal disturbances upon the regulation of these AQPs. Chronic ethanol intake significantly decreased body weight, while UChA and UChB rats displayed a marked loss of epididymal weights. Both ethanol-consuming animals had a severe reduction of testosterone levels, whereas LH and 17β-estradiol were unchanged. Throughout the epididymis, a strong reaction to AQP-1 was observed in myoid and endothelial cells of the UChB ethanol-preferring rats, differently from a moderate intensity in the initial segment of the UChA rats. In addition, AQP-9 showed a strong immunoreaction in the apical membrane of principal cells at initial segment. In cauda epididymis, the level of AQP-9 was reduced along the microvillus projections in both UChA and UChB rats compared to controls. We conclude that chronic ethanol consumption modulates the androgen levels, thereby modifying the expression pattern of AQP-1 and 9 in the epididymis. © 2011 Elsevier Ltd.
Issue Date: 
1-Feb-2012
Citation: 
Tissue and Cell, v. 44, n. 1, p. 47-53, 2012.
Time Duration: 
47-53
Keywords: 
  • AQP-1 and AQP-9
  • Epididymis
  • Ethanol
  • UCh rats
  • alcohol
  • androgen
  • aquaporin 1
  • aquaporin 9
  • estradiol
  • luteinizing hormone
  • testosterone
  • alcohol consumption
  • animal cell
  • animal experiment
  • animal model
  • animal tissue
  • apical membrane
  • body weight
  • controlled study
  • endocrine disease
  • endothelium cell
  • epididymis disease
  • epididymis tail
  • immunoreactivity
  • long term exposure
  • male
  • microvillus
  • nonhuman
  • organ weight
  • protein expression
  • rat
  • regulatory mechanism
  • Animals
  • Aquaporin 1
  • Aquaporins
  • Immunohistochemistry
  • Male
  • Rats
  • Rats, Wistar
  • Testosterone
  • Animalia
  • Myoida
  • Rattus
Source: 
http://dx.doi.org/10.1016/j.tice.2011.11.001
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/73176
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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