Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/74159
- Title:
- Physical exercise modulates peripheral levels of brain-derived neurotrophic factor (BDNF): A systematic review of experimental studies in the elderly
- Universidade Estadual Paulista (UNESP)
- Universidade Federal do ABC (UFABC)
- 0167-4943
- 1872-6976
- The objective of this study was to conduct a systematic review of studies that analyzed the effect of physical exercise on the peripheral levels of BDNF in elderly individuals. Method: We conducted a search in PsycINFO, Biological Abstracts, Pubmed, Web of Science, and Science Direct from 1990 to 2011, using the following keywords: physical exercise , physical activity , physical therapy , training , BDNF , neuroplasticity , neurotrophins , neuroplasticity proteins , aged , older , elderly The articles were considered for inclusion in the review if they were studies with elderly, assessed peripheral (serum and/or plasma) BDNF and evaluated an acute exercise or chronic exercise (training). Results: Five randomized controlled trial and one randomized non-controlled trial studies were analyzed. Five out of six studies reported a significantly higher BDNF response to aerobic acute exercise and to aerobic or strength training program in healthy elderly and elderly with different pathologies. Conclusion: It was not possible to establish a recommendation protocol for the type and intensity of physical exercise required to produce an increase in levels BDNF. However, physical exercise, particularly, moderate-intensity exercises seem to be more effective to promote increase the peripheral levels of BDNF in the elderly. © 2012 Elsevier B.V.
- 1-Jan-2013
- Archives of Gerontology and Geriatrics, v. 56, n. 1, p. 10-15, 2013.
- 10-15
- Aging
- BDNF
- Biomarkers
- Physical activity
- Review
- brain derived neurotrophic factor
- aerobic exercise
- clinical effectiveness
- exercise intensity
- experimental study
- geriatric patient
- human
- physical activity
- priority journal
- randomized controlled trial (topic)
- resistance training
- review
- systematic review (topic)
- Aged
- Brain-Derived Neurotrophic Factor
- Exercise
- Humans
- http://dx.doi.org/10.1016/j.archger.2012.06.003
- Acesso restrito
- outro
- http://repositorio.unesp.br/handle/11449/74159
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