Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid

Silva, M.; Lara, A. S.; Leite, CQF; Ferreira, E. I.

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/7577

Title:

Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid

Author(s):

Institution:

Universidade Estadual Paulista (UNESP)
Universidade de São Paulo (USP)

ISSN:

0365-6233

Abstract:

With the objective of obtaining slow-acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle-forming copolymer of poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium Il(tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug.

Issue Date:

1-Jun-2001

Citation:

Archiv Der Pharmazie. Berlin: Wiley-v C H Verlag Gmbh, v. 334, n. 6, p. 189-193, 2001.

Time Duration:

189-193

Publisher:

Wiley-Blackwell

Keywords:

potential tuberculostatic agent
isoniazid
prodrug
micelle-forming polymer
co-polymer poly(ethylene glycol)-poly(aspartic acid)

Source:

http://dx.doi.org/10.1002/1521-4184(200106)334:6<189

URI:

Access Rights:

Acesso restrito

Type:

outro

Source:

http://repositorio.unesp.br/handle/11449/7577

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