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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/75887
Title: 
New isoniazid complexes, promising agents against mycobacterium tuberculosis
Author(s): 
Institution: 
  • Universidad de la República
  • Universidade de São Paulo (USP)
  • Universidade Estadual Paulista (UNESP)
ISSN: 
  • 1870-249X
  • 1665-9686
Sponsorship: 
  • CYTED network
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
  • ANII
Sponsorship Process Number: 
  • CYTED network209RT0380
  • FAPESP: 09/06499-1
  • FAPESP: 11/11593-7
  • ANIIBE_INI_2010_1851
Abstract: 
Tuberculosis (TB) is a public health disease that produces several million deaths annually worldwide. Due to this critical situation and the appearance of drug-resistant microbial strains, innovation in TB drug discovery is a research priority. In this work, the synthesis and characterization by elemental analysis, thermogravimetry, conductimetric measurements and spectroscopies UV-Vis, IR and EPR of [Cu(INH)(H2O)]SO4·2H2O (Cu-INH) and [CoCl(INH)2(H2O)] Cl·2.5H2O (Co-INH) complexes with isoniazid (INH) are reported. Besides, the lipophilicity, the activity against Mycobacterium tuberculosis (MICCu-INH = 0.78 μg/mL and MICCo-INH = 0.19 μg/mL) and the cytotoxicity (IC50 = 48.8 and 625 μg/mL for the copper and cobalt complexes, respectively) were measured and the selectivity index (62.5 for Cu-INH and 3205 for Co-INH) was calculated. These results indicate that these complexes are good candidates for further studies. © 2013, Sociedad Química de México.
Issue Date: 
1-Jul-2013
Citation: 
Journal of the Mexican Chemical Society, v. 57, n. 3, p. 198-204, 2013.
Time Duration: 
198-204
Keywords: 
  • Antimycobacteria activity
  • Copper and cobalt complexes
  • Isoniazid
  • Spectroscopy
  • Tuberculosis
Source: 
http://www.jmcs.org.mx/PDFS/V57/3/06.-%20Poggi.pdf
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/75887
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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