Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/75887
- Title:
- New isoniazid complexes, promising agents against mycobacterium tuberculosis
- Universidad de la República
- Universidade de São Paulo (USP)
- Universidade Estadual Paulista (UNESP)
- 1870-249X
- 1665-9686
- CYTED network
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- ANII
- CYTED network209RT0380
- FAPESP: 09/06499-1
- FAPESP: 11/11593-7
- ANIIBE_INI_2010_1851
- Tuberculosis (TB) is a public health disease that produces several million deaths annually worldwide. Due to this critical situation and the appearance of drug-resistant microbial strains, innovation in TB drug discovery is a research priority. In this work, the synthesis and characterization by elemental analysis, thermogravimetry, conductimetric measurements and spectroscopies UV-Vis, IR and EPR of [Cu(INH)(H2O)]SO4·2H2O (Cu-INH) and [CoCl(INH)2(H2O)] Cl·2.5H2O (Co-INH) complexes with isoniazid (INH) are reported. Besides, the lipophilicity, the activity against Mycobacterium tuberculosis (MICCu-INH = 0.78 μg/mL and MICCo-INH = 0.19 μg/mL) and the cytotoxicity (IC50 = 48.8 and 625 μg/mL for the copper and cobalt complexes, respectively) were measured and the selectivity index (62.5 for Cu-INH and 3205 for Co-INH) was calculated. These results indicate that these complexes are good candidates for further studies. © 2013, Sociedad Química de México.
- 1-Jul-2013
- Journal of the Mexican Chemical Society, v. 57, n. 3, p. 198-204, 2013.
- 198-204
- Antimycobacteria activity
- Copper and cobalt complexes
- Isoniazid
- Spectroscopy
- Tuberculosis
- http://www.jmcs.org.mx/PDFS/V57/3/06.-%20Poggi.pdf
- Acesso restrito
- outro
- http://repositorio.unesp.br/handle/11449/75887
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