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dc.contributor.advisorArni, Raghuvir Krishnaswamy [UNESP]-
dc.contributor.authorMurakami, Mario Tyago-
dc.identifier.citationMURAKAMI, Mario Tyago. Estratégias de inibição, mecanismos moleculares e interações intermoleculares em complexos macromoleculares. 2006. 152 f. Tese (doutorado) - Universidade Estadual Paulista, Instituto de Biociências, Letras e Ciências Exatas, 2006.-
dc.description.abstractThis work presents some features of essential biological processes such as the haemostatic system, integrity of biological membranes and thermostability of proteins. Crystallographic, spectroscopic and in silico tools have been used to obtain information at the molecular level of macromolecular complexes, action mechanisms and inhibition pathways. Worms, snakes, ticks, leeches and spiders produce a variety of proteins, which interfere in the regulation of these systems. Different toxins isolated from these organisms were characterized providing necessary information for the development of a new anti-myonecrotic molecule and reveal a new factor Xa exosite that is important for macromolecular substrates recognition and inhibition. The first crystal structure of a member of the sphingomyelinases D family was determined by the quick cryo-soaking technique and the catalytic mechanism was proposed, which involves a magnesium-binding site and two catalytic histidines. An alternative activation of the protein C pathway that does not require thrombomodulin was structurally characterized and revealed the dual role of the elestrotatic surface charge around the active site and the three strategically positioned carbohydrate moieties in the approach, recognition and activation of protein C.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent152 f. : il.-
dc.publisherUniversidade Estadual Paulista (UNESP)-
dc.subjectProteínas - Estruturapt
dc.subjectRaios X - Difraçãopt
dc.subjectCristalografia de raio Xpt
dc.subjectSangue - Coagulaçãopt
dc.subjectDifração de raios Xpt
dc.subjectCoagulação sanguíneapt
dc.subjectProcessos biológicospt
dc.subjectMecanismos de ação e inibiçãopt
dc.subjectX-ray diffractionen
dc.subjectBiological processesen
dc.subjectAction mechanisms and inhibitionen
dc.titleEstratégias de inibição, mecanismos moleculares e interações intermoleculares em complexos macromolecularespt
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.rights.accessRightsAcesso aberto-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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