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Exercise training attenuates acute hyperalgesia in streptozotocin-induced diabetic female rats
  • Universidade Estadual Paulista (UNESP)
  • Universidade de São Paulo (USP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
OBJECTIVES: We investigated the effects of chronic (eight weeks) low-to moderate-intensity swimming training on thermal pain sensitivity in streptozotocin-induced diabetic female rats. METHODS: Female Wistar rats (n = 51) were divided into the following groups: trained streptozotocin-induced diabetic rats [hyperglycemic trained (HT)], sedentary streptozotocin-induced diabetic rats [hyperglycemic sedentary (HS)], normoglycemic trained rats (NT) and normoglycemic sedentary rats (NS). Diabetes was induced by a single injection of streptozotocin (50 mg/kg, i.p.). One day after the last exercise protocol (60 min/day, five days/week for eight weeks) in the trained groups or after water stress exposure (ten min/twice a week) in the sedentary groups, the rats were subjected to a hot plate test. RESULTS: After eight weeks of swimming training, streptozotocin-induced diabetic rats presented a significantly lower body mass (trained: 219.5±29 g, sedentary: 217.8±23 g) compared with the normoglycemic groups (trained: 271±24 g, sedentary: 275.7±32 g). Interestingly, we did not find differences in blood glucose levels (mg/dl) between the trained and sedentary groups of the hyperglycemic or normoglycemic rats (HT: 360.2±6.6, HS: 391.7±6.7, NT: 83.8±14.0, NS: 77.5±10.1). In the hot plate test, the rats from the HT group presented a significantly lower latency than the other rats (HT: 11.7±7.38 s, HS: 7.02±7.38 s, NT: 21.21±7.64 s, NS: 22.82±7.82 s). CONCLUSION: Low-to-moderate swimming training for a long duration reduces thermal hyperalgesia during a hot plate test in streptozotocin-induced diabetic female rats.
Issue Date: 
Clinics. Faculdade de Medicina / USP, v. 66, n. 9, p. 1615-1619, 2011.
Time Duration: 
Universidade de São Paulo (USP), Faculdade de Medicina
  • Diabetes mellitus
  • Diabetic neuropathy
  • Pain sensitivity
  • Physical exercise
  • Swimming training
  • Hot plate test
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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