You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/10763
Full metadata record
DC FieldValueLanguage
dc.contributor.authorValenti, Vitor Engrácia-
dc.contributor.authorAbreu, Luiz Carlos de-
dc.contributor.authorSato, Monica A.-
dc.contributor.authorFerreira, Celso-
dc.contributor.authorAdami, Fernando-
dc.contributor.authorFonseca, Fernando L. A.-
dc.contributor.authorXavier, Valdelias-
dc.contributor.authorGodoy, Moacir-
dc.contributor.authorMonteiro, Carlos B.-
dc.contributor.authorVanderlei, Luiz Carlos M.-
dc.contributor.authorSaldiva, Paulo H. N.-
dc.date.accessioned2014-05-20T13:31:35Z-
dc.date.available2014-05-20T13:31:35Z-
dc.date.issued2012-03-30-
dc.identifierhttp://dx.doi.org/10.1186/1471-2261-12-22-
dc.identifier.citationBmc Cardiovascular Disorders. London: Biomed Central Ltd., v. 12, p. 13, 2012.-
dc.identifier.issn1471-2261-
dc.identifier.urihttp://hdl.handle.net/11449/10763-
dc.description.abstractBackground: Cigarette exposure increases brain oxidative stress. The literature showed that increased brain oxidative stress affects cardiovascular regulation. However, no previous study investigated the involvement of brain oxidative stress in animals exposed to cigarette and its relationship with cardiovascular regulation. We aimed to evaluate the effects of central catalase inhibition on baroreflex and cardiovascular responses in rats exposed to sidestream cigarette smoke (SSCS).Methods: We evaluated males Wistar rats (320-370 g), which were implanted with a stainless steel guide cannula into the fourth cerebral ventricle (4th V). Femoral artery and vein were cannulated for mean arterial pressure (MAP) and heart rate (HR) measurement and drug infusion, respectively. Rats were exposed to SSCS during three weeks, 180 minutes, 5 days/week (CO: 100-300 ppm). Baroreflex was tested with a pressor dose of phenylephrine (PHE, 8 mu g/kg, bolus) to induce bradycardic reflex and a depressor dose of sodium nitroprusside (SNP, 50 mu g/kg, bolus) to induce tachycardic reflex. Cardiovascular responses were evaluated before, 5, 15, 30 and 60 minutes after 3-amino-1,2,4-triazole (ATZ, catalase inhibitor, 0.001 g/100 mu L) injection into the 4th V.Results: Central catalase inhibition increased basal HR in the control group during the first 5 minutes. SSCS exposure increased basal HR and attenuated bradycardic peak during the first 15 minutes.Conclusion: We suggest that SSCS exposure affects cardiovascular regulation through its influence on catalase activity.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent13-
dc.language.isoeng-
dc.publisherBiomed Central Ltd.-
dc.sourceWeb of Science-
dc.titleSidestream cigarette smoke effects on cardiovascular responses in conscious rats: involvement of oxidative stress in the fourth cerebral ventricleen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionFac Med ABC-
dc.contributor.institutionFac Med Sao Jose do Rio Preto-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Ciencias & Tecnol, Programa Posgrad Fisioterapia, Presidente Prudente, SP, Brazil-
dc.description.affiliationFac Med ABC, Dept Morfol & Fisiol, Santo Andre, SP, Brazil-
dc.description.affiliationFac Med Sao Jose do Rio Preto, Dept Cardiol & Cirurgia Cardiovasc, São Paulo, Brazil-
dc.description.affiliationUniv São Paulo, Fac Med, Dept Patol, São Paulo, Brazil-
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Filosofia Ciencias, Dept Fonoaudiol, BR-17525900 Marilia, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Ciencias & Tecnol, Programa Posgrad Fisioterapia, Presidente Prudente, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Filosofia Ciencias, Dept Fonoaudiol, BR-17525900 Marilia, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 07/59127-9-
dc.identifier.doi10.1186/1471-2261-12-22-
dc.identifier.wosWOS:000304147500001-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileWOS000304147500001.pdf-
dc.relation.ispartofBMC Cardiovascular Disorders-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.