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dc.contributor.authorAndrade, N. S.-
dc.contributor.authorPerazzo, F. F.-
dc.contributor.authorMaistro, Edson Luis-
dc.date.accessioned2014-05-20T13:31:44Z-
dc.date.available2014-05-20T13:31:44Z-
dc.date.issued2008-01-01-
dc.identifierhttp://dx.doi.org/10.4238/vol7-4gmr546-
dc.identifier.citationGenetics and Molecular Research. Ribeirao Preto: Funpec-editora, v. 7, n. 4, p. 1414-1421, 2008.-
dc.identifier.issn1676-5680-
dc.identifier.urihttp://hdl.handle.net/11449/10809-
dc.description.abstractBaccharis dracunculifolia de Candole (DC) ( Asteraceae) is indigenous throughout southeastern Latin America and is used by local people in traditional medicine. This plant is known to be the source of resin for the highly valued Brazilian green propolis. As no information is available on the safety of high doses of B. dracunculifolia extract, we evaluated the mutagenic potential of high doses of this plant extract in vivo on peripheral blood cells of Swiss mice using the comet assay and the micronucleus test. The extract was administered by gavage at doses of 1000, 1500 and 2000 mg/kg body weight. Peripheral blood cell samples were collected 4 and 24 h after treatment for the comet assay (genotoxicity assay), and at 48 and 72 h for the micronucleus test (clastogenicity assay). The B. dracunculifolia extract was devoid of clastogenic/genotoxic activity at all doses.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent1414-1421-
dc.language.isoeng-
dc.publisherFunpec-editora-
dc.sourceWeb of Science-
dc.subjectBaccharis dracunculifoliaen
dc.subjectMicronucleus testen
dc.subjectSingle cell gel electrophoresisen
dc.subjectMutagenicity assayen
dc.titleLack of clastogenic/genotoxic effects of Baccharis dracunculifolia extract on Swiss mouse peripheral blood cellsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniv Jose Rosario Vellano-
dc.contributor.institutionUniversidade Federal do Amapá (UNIFAP)-
dc.description.affiliationUniv Estadual Paulista, Fac Filosofia & Ciencias, Dept Fonoaudiol, Marilia, SP, Brazil-
dc.description.affiliationUniv Jose Rosario Vellano, Genet Lab, Alfenas, MG, Brazil-
dc.description.affiliationUniv Fed Amapa, Lab Pesquisa Farmacos, Macapa, AP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Filosofia & Ciencias, Dept Fonoaudiol, Marilia, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 06/57514-2-
dc.description.sponsorshipIdFAPEMIG: 1879/02-
dc.description.sponsorshipIdCNPq: 306544/2006-7-
dc.identifier.doi10.4238/vol7-4gmr546-
dc.identifier.wosWOS:000267218200032-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileWOS000267218200032.pdf-
dc.relation.ispartofGenetics and Molecular Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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