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dc.contributor.authorDa Silva, Thiago Henrique Gomes-
dc.contributor.authorPazetti, Rogerio-
dc.contributor.authorAoki, Fabio Gava-
dc.contributor.authorCardoso, Paulo Francisco Guerreiro-
dc.contributor.authorValenga, Marcelo Henrique-
dc.contributor.authorDeffune, Elenice-
dc.contributor.authorEvaristo, Thaiane-
dc.contributor.authorPêgo-fernandes, Paulo Manuel-
dc.contributor.authorMoriya, Henrique Takachi-
dc.identifier.citationClinics. Faculdade de Medicina / USP, v. 69, n. 7, p. 500-503, 2014.-
dc.description.abstractOBJECTIVES: Despite the recent success regarding the transplantation of tissue-engineered airways, the mechanical properties of these grafts are not well understood. Mechanical assessment of a tissue-engineered airway graft before implantation may be used in the future as a predictor of function. The aim of this preliminary work was to develop a noninvasive image-processing environment for the assessment of airway mechanics.METHOD: Decellularized, recellularized and normal tracheas (groups DECEL, RECEL, and CONTROL, respectively) immersed in Krebs-Henseleit solution were ventilated by a small-animal ventilator connected to a Fleisch pneumotachograph and two pressure transducers (differential and gauge). A camera connected to a stereomicroscope captured images of the pulsation of the trachea before instillation of saline solution and after instillation of Krebs-Henseleit solution, followed by instillation with Krebs-Henseleit with methacholine 0.1 M (protocols A, K and KMCh, respectively). The data were post-processed with computer software and statistical comparisons between groups and protocols were performed.RESULTS: There were statistically significant variations in the image measurements of the medial region of the trachea between the groups (two-way analysis of variance [ANOVA], p<0.01) and of the proximal region between the groups and protocols (two-way ANOVA, p<0.01).CONCLUSIONS: The technique developed in this study is an innovative method for performing a mechanical assessment of engineered tracheal grafts that will enable evaluation of the viscoelastic properties of neo-tracheas prior to transplantation.en
dc.publisherUniversidade de São Paulo (USP), Faculdade de Medicina-
dc.subjectRespiratory Mechanicsen
dc.titleAssessment of the mechanics of a tissue-engineered rat trachea in an image-processing environmenten
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniversidade de São Paulo Escola Politécnica Biomedical Engineering Laboratory-
dc.description.affiliationUniversidade de São Paulo Faculdade de Medicina Hospital das Clínicas-
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Tissue Engineering Laboratory-
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Tissue Engineering Laboratory-
dc.rights.accessRightsAcesso aberto-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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