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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/109798
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dc.contributor.authorMinossi, José Guilherme-
dc.contributor.authorLima, Flávio de Oliveira-
dc.contributor.authorCaramori, Carlos Antonio-
dc.contributor.authorHasimoto, Claudia Nishida-
dc.contributor.authorOrtolan, Erica Veruska Paiva-
dc.contributor.authorRodrigues, Paulo Antônio-
dc.contributor.authorSpadella, César Tadeu-
dc.date.accessioned2014-10-01T13:08:34Z-
dc.date.accessioned2016-10-25T19:45:05Z-
dc.date.available2014-10-01T13:08:34Z-
dc.date.available2016-10-25T19:45:05Z-
dc.date.issued2014-02-01-
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502014000200008-
dc.identifier.citationActa Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 29, n. 2, p. 118-124, 2014.-
dc.identifier.issn0102-8650-
dc.identifier.urihttp://hdl.handle.net/11449/109798-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/109798-
dc.description.abstractPURPOSE:To investigate the effects of alloxan diabetes on the abdominal wall healing of rats undergoing laparotomy.METHODS:Ninety-six male Wistar rats weighing between 200 and 300 grams, divided into two groups: non-diabetic group (G1) and another with untreated diabetes (G2). Three months after diabetes induction, the animals underwent a 5cm-long- laparotomy and 5.0 nylon monofilament suture. After the surgery, 12 animals from each group were euthanized on days 4, 14, 21 and 30 corresponding to the moments M1, M2, M3 and M4. In each moment a fragment of the abdominal wall containing the scar was removed for tensile strength measurement, histological and morphometric study. Clinical and biochemical parameters were also analyzed.RESULTS:G2 animals showed parameters compatible with severe diabetes and decreased plasma levels of insulin. The tensile strength in G2 was significantly smaller in M2 and M4, with a tendency to fall in the other two. Through light microscope, diabetic animals showed more difficulty to increase collagen density and contraction. G2 animals showed high cellularity of fibroblasts in later healing moments, with collagen thinning in M2 and M4.CONCLUSION:The abdominal wound healing in untreated diabetic animals was altered and led to a higher incidence of dehiscence and infections.en
dc.format.extent118-124-
dc.language.isoeng-
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia-
dc.sourceSciELO-
dc.subjectDiabetes Mellitusen
dc.subjectAlloxanen
dc.subjectTensile Strengthen
dc.subjectWound Healingen
dc.subjectHistologyen
dc.subjectRatsen
dc.titleAlloxan diabetes alters the tensile strength, morphological and morphometric parameters of abdominal wall healing in ratsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationSao Paulo State University Faculty of Medicine Departament of Surgery and Orthopedics-
dc.description.affiliationUNESP Faculty of Medicine Department of Pathology-
dc.description.affiliationUNESP Faculty of Medicine Department of Medical Clinic-
dc.description.affiliationUNESP Faculty of Medicine-
dc.description.affiliationUNESP Faculty of Medicine Department of Surgery and Orthopedics-
dc.description.affiliationUnespSao Paulo State University Faculty of Medicine Departament of Surgery and Orthopedics-
dc.description.affiliationUnespUNESP Faculty of Medicine Department of Pathology-
dc.description.affiliationUnespUNESP Faculty of Medicine Department of Medical Clinic-
dc.description.affiliationUnespUNESP Faculty of Medicine-
dc.description.affiliationUnespUNESP Faculty of Medicine Department of Surgery and Orthopedics-
dc.identifier.doi10.1590/S0102-86502014000200008-
dc.identifier.scieloS0102-86502014000200118-
dc.identifier.wosWOS:000333046900008-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileS0102-86502014000200118.pdf-
dc.relation.ispartofActa Cirúrgica Brasileira-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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