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DC Field | Value | Language |
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dc.contributor.author | Mello Ayres Putinatti, Maria Stella de | - |
dc.contributor.author | Lastoria, Joel Carlos | - |
dc.contributor.author | Padovani, Carlos Roberto | - |
dc.date.accessioned | 2014-12-03T13:07:02Z | - |
dc.date.accessioned | 2016-10-25T19:48:08Z | - |
dc.date.available | 2014-12-03T13:07:02Z | - |
dc.date.available | 2016-10-25T19:48:08Z | - |
dc.date.issued | 2014-03-01 | - |
dc.identifier | http://dx.doi.org/10.1590/abd1806-4841.20142037 | - |
dc.identifier.citation | Anais Brasileiros De Dermatologia. Rio De Janeiro Rj: Soc Brasileira Dermatologia, v. 89, n. 2, p. 266-272, 2014. | - |
dc.identifier.issn | 0365-0596 | - |
dc.identifier.uri | http://hdl.handle.net/11449/111183 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/111183 | - |
dc.description.abstract | BACKGROUND: Leprosy can have its course interrupted by type 1 and 2 reactional episodes, the last named of erythema nodosum leprosum (ENL). Thalidomide has been the medication of choice for the control of ENL episodes since 1965. OBJECTIVES: These episodes can repeat and cause damages to the patient. In order to prevent these episodes, an extra dose of 100 mg/day thalidomide was used during six months, followed by a follow-up period of six more months after thalidomide discontinuation. METHODS: We included 42 patients with multibacillary (MB) leprosy who had episodes of ENL. They were male and female patients aged between 18 and 84 years. RESULTS: Of the 42 patients, 39 (92.85%) had the lepromatous form and three (7.15%) had the borderline form. We found that 100% of patients had no reactional episode during the use of the drug. During the follow-up period after thalidomide discontinuation, 33 (78.57%) patients had no reactional episode and nine (21.43%), all of them with the lepromatous form, had mild episodes, which were controlled using non-steroidal anti-inflammatory. There were no thalidomide-related side effects. CONCLUSION: A maintenance dose of 100 mg/day of thalidomide showed to be effective to prevent repeated type 2 reactional episodes of ENL. | en |
dc.format.extent | 266-272 | - |
dc.language.iso | eng | - |
dc.publisher | Soc Brasileira Dermatologia | - |
dc.source | Web of Science | - |
dc.subject | Erythema nodosum | en |
dc.subject | Leprosy | en |
dc.subject | Medication therapy management | en |
dc.subject | Thalidomide | en |
dc.title | Prevention of repeated episodes of type 2 reaction of leprosy with the use of thalidomide 100 mg/day | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Univ Estadual Paulista Julio de Mesquita Filho Un, Botucatu, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista Julio de Mesquita Filho Un, Botucatu, SP, Brazil | - |
dc.identifier.doi | 10.1590/abd1806-4841.20142037 | - |
dc.identifier.scielo | S0365-05962014000200266 | - |
dc.identifier.wos | WOS:000335171600009 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.identifier.file | S0365-05962014000200266.pdf | - |
dc.relation.ispartof | Anais Brasileiros de Dermatologia | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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