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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/111301
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dc.contributor.authorSchmitz, Ariana Ern-
dc.contributor.authorOliveira, Paulo Alexandre de-
dc.contributor.authorSouza, Luiz F. de-
dc.contributor.authorHumberto da Silva, Danilo Gruenig-
dc.contributor.authorDanielski, Samara-
dc.contributor.authorSantos, Danubia Bonfanti-
dc.contributor.authorAlmeida, Eduardo Alves de-
dc.contributor.authorPrediger, Rui Daniel-
dc.contributor.authorFisher, Andrew-
dc.contributor.authorFarina, Marcelo-
dc.contributor.authorDafre, Alcir Luiz-
dc.date.accessioned2014-12-03T13:07:09Z-
dc.date.accessioned2016-10-25T19:58:52Z-
dc.date.available2014-12-03T13:07:09Z-
dc.date.available2016-10-25T19:58:52Z-
dc.date.issued2014-06-01-
dc.identifierhttp://dx.doi.org/10.1007/s12011-014-9951-5-
dc.identifier.citationBiological Trace Element Research. Totowa: Humana Press Inc, v. 158, n. 3, p. 399-409, 2014.-
dc.identifier.issn0163-4984-
dc.identifier.urihttp://hdl.handle.net/11449/111301-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/111301-
dc.description.abstractManganese (Mn) exposure is related to industrial activities, where absorption by inhalation has high relevance. Manganism, a syndrome caused as a result of excessive accumulation of Mn in the central nervous system, has numerous symptoms similar to those seen in idiopathic Parkinson disease (IPD). Some of these symptoms, such as learning, memory, sensorial, and neurochemical changes, appear before the onset of motor deficits in both manganism and IPD. The aim of this study was to evaluate the possible neuroprotective effects of curcumin against behavioral deficits induced by Mn toxicity in young (2 months old) Swiss mice. We evaluated the effect of chronic inhalation of a Mn mixture [Mn(OAc)(3) and MnCl2 (20:40 mM)], 1 h/session, three times a week, over a 14-week period on behavioral and neurochemical parameters. Curcumin was supplemented in the diet (500 or 1,500 ppm in food pellets). The Mn disrupted the motor performance evaluated in the single-pellet reach task, as well as the short- and long-term spatial memory evaluated in the step-down inhibitory avoidance task. Surprisingly, curcumin also produced similar deleterious effects in such behavioral tests. Moreover, the association of Mn plus curcumin significantly increased the levels of Mn and iron, and decreased the levels of dopamine and serotonin in the hippocampus. These alterations were not observed in the striatum. In conclusion, the current Mn treatment protocol resulted in mild deficits in motor and memory functions, resembling the early phases of IPD. Additionally, curcumin showed no beneficial effects against Mn-induced disruption of hippocampal metal and neurotransmitter homeostasis.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipFINEP Research Grant Rede Instituto Brasileiro de Neurociencia (IBN-Net)-
dc.description.sponsorshipINCT-Excitotoxicity and Neuroprotection-
dc.description.sponsorshipFAPESC (Foundation for the Support of Scientific and Technological Research in the State of Santa Catarina)-
dc.format.extent399-409-
dc.language.isoeng-
dc.publisherHumana Press Inc-
dc.sourceWeb of Science-
dc.subjectManganeseen
dc.subjectCurcuminen
dc.subjectIdiopathic Parkinson diseaseen
dc.subjectMemoryen
dc.subjectMotor performanceen
dc.titleInteraction of Curcumin with Manganese May Compromise Metal and Neurotransmitter Homeostasis in the Hippocampus of Young Miceen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniv Plymouth-
dc.description.affiliationUniv Fed Santa Catarina, Dept Biochem, Ctr Biol Sci, BR-88040900 Florianopolis, SC, Brazil-
dc.description.affiliationUniv Fed Santa Catarina, Dept Pharmacol, BR-88040900 Florianopolis, SC, Brazil-
dc.description.affiliationUniv Paulista Julio de Mesquita Filho, Dept Chem & Environm Sci, Sao Paulo, Brazil-
dc.description.affiliationUniv Plymouth, Sch Geog Earth & Environm Sci, Plymouth PL4 8AA, Devon, England-
dc.description.affiliationUnespUniv Paulista Julio de Mesquita Filho, Dept Chem & Environm Sci, Sao Paulo, Brazil-
dc.description.sponsorshipIdFINEP Research Grant Rede Instituto Brasileiro de Neurociencia (IBN-Net)01.06.0842-00-
dc.identifier.doi10.1007/s12011-014-9951-5-
dc.identifier.wosWOS:000335771800017-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofBiological Trace Element Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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