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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/111433
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dc.contributor.authorSantos, Glauco Pilon dos-
dc.contributor.authorSilva, Bianca Ferreira da-
dc.contributor.authorGarrido, Saulo Santesso-
dc.contributor.authorMascini, Marcello-
dc.contributor.authorYamanaka, Hideko-
dc.date.accessioned2014-12-03T13:08:39Z-
dc.date.accessioned2016-10-25T20:08:30Z-
dc.date.available2014-12-03T13:08:39Z-
dc.date.available2016-10-25T20:08:30Z-
dc.date.issued2014-01-01-
dc.identifierhttp://dx.doi.org/10.1039/c3an01498c-
dc.identifier.citationAnalyst. Cambridge: Royal Soc Chemistry, v. 139, n. 1, p. 273-279, 2014.-
dc.identifier.issn0003-2654-
dc.identifier.urihttp://hdl.handle.net/11449/111433-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/111433-
dc.description.abstractThis paper describes the molecular modeling design, synthesis and characterization of a new bio-inspired hexapeptide of acetylcholinesterase enzyme and its interaction with the organophosphate pesticide dichlorvos monitored by UV-Vis spectroscopy and mass spectrometry. This strategy can contribute to the development of synthetic receptors to be coupled to biosensor transducers, avoiding the issues associated with proteins such as low stability under different pH and temperature conditions and high production cost. The resulting data of this work indicate a strong interaction between the pesticide dichlorvos and the hexapeptide (NH3+-Glu-His-Gly-Gly-Pro-Ser-COO-) with a binding constant of 4.10 x 10(5) M-1 and the formation of an adduct by covalent binding on the serine residue from the hexapeptide.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipFP7-PEOPLE-IRSES project-
dc.format.extent273-279-
dc.language.isoeng-
dc.publisherRoyal Soc Chemistry-
dc.sourceWeb of Science-
dc.titleDesign, synthesis and characterization of a hexapeptide bio-inspired by acetylcholinesterase and its interaction with pesticide dichlorvosen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniv Teramo-
dc.description.affiliationUNESP Univ Estadual Paulista, Inst Chem, BR-14800900 Araraquara, SP, Brazil-
dc.description.affiliationUniv Teramo, Fac Biosci & Technol Food Agr & Environm, I-64023 Teramo, Italy-
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Inst Chem, BR-14800900 Araraquara, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 10/04663-6-
dc.description.sponsorshipIdCNPq: 313307/2009-1-
dc.description.sponsorshipIdFP7-PEOPLE-IRSES projectBIOMIMIC 230849-
dc.identifier.doi10.1039/c3an01498c-
dc.identifier.wosWOS:000327548400035-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofAnalyst-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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