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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/111852
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dc.contributor.authorRothmund, Friederike-
dc.contributor.authorGerss, Joachim-
dc.contributor.authorRuperto, Nicolino-
dc.contributor.authorDaebritz, Jan-
dc.contributor.authorWittkowski, Helmut-
dc.contributor.authorFrosch, Michael-
dc.contributor.authorWulffraat, Nico M.-
dc.contributor.authorWedderburn, Lucy R.-
dc.contributor.authorHolzinger, Dirk-
dc.contributor.authorGohar, Faekah-
dc.contributor.authorVastert, Sebastiaan J.-
dc.contributor.authorBrik, Riva-
dc.contributor.authorDeslandre, Chantal Job-
dc.contributor.authorMelo-Gomes, Jose Antonio-
dc.contributor.authorMagalhães, Cláudia Saad-
dc.contributor.authorBarcellona, Roberto-
dc.contributor.authorRusso, Ricardo-
dc.contributor.authorGattorno, Marco-
dc.contributor.authorMartini, Alberto-
dc.contributor.authorRoth, Johannes-
dc.contributor.authorFoell, Dirk-
dc.contributor.authorPRINTO-
dc.date.accessioned2014-12-03T13:09:02Z-
dc.date.accessioned2016-10-25T20:09:52Z-
dc.date.available2014-12-03T13:09:02Z-
dc.date.available2016-10-25T20:09:52Z-
dc.date.issued2014-06-01-
dc.identifierhttp://dx.doi.org/10.1002/acr.22248-
dc.identifier.citationArthritis Care & Research. Hoboken: Wiley-blackwell, v. 66, n. 6, p. 949-955, 2014.-
dc.identifier.issn2151-464X-
dc.identifier.urihttp://hdl.handle.net/11449/111852-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/111852-
dc.description.abstractObjective. The myeloid-related proteins 8 and 14 (MRP-8/MRP-14) and neutrophil-derived S100A12 are biomarkers of inflammation. They can be used to determine the relapse risk in patients with juvenile idiopathic arthritis (JIA) after stopping antiinflammatory treatment. In this study, we tested the performance of different enzyme-linked immunosorbent assays (ELISAs) in order to validate systems available for routine use.Methods. MRP-8/MRP-14 and S100A12 serum concentrations of 188 JIA patients in remission were analyzed. Commercially available test systems were compared to experimental ELISAs established in house. The ability of the assays to identify JIA patients at risk for relapse was analyzed.Results. For MRP-8/MRP-14, the PhiCal Calprotectin and Buhlmann MRP8/14 Calprotectin ELISAs revealed hazard ratios of 2.3 and 2.1, respectively. For S100A12, the CircuLex S100A12/EN-RAGE ELISA revealed a hazard ratio of 3.1. The commercial assays allowed a JIA relapse prediction that was at least comparable to the experimental ELISAs.Conclusion. For the prediction of JIA relapse after stopping medication, the biomarkers MRP-8/MRP-14 and S100A12 can be determined by using assays that are available for routine use. The tested commercial MRP-8/MRP-14 and S100A12 ELISAs showed a performance comparable to well-established experimental ELISA protocols when assay-specific cutoffs for the indication of relapse prediction are thoroughly applied.en
dc.description.sponsorshipInterdisciplinary Centre of Clinical Research at the University of Munster (IZKF)-
dc.description.sponsorshipSparks-
dc.description.sponsorshipEuropean Union-
dc.description.sponsorshipPRINTO (Paediatric Rheumatology International Trials Organisation)-
dc.description.sponsorshipNovartis-
dc.format.extent949-955-
dc.language.isoeng-
dc.publisherWiley-Blackwell-
dc.sourceWeb of Science-
dc.titleValidation of Relapse Risk Biomarkers for Routine Use in Patients With Juvenile Idiopathic Arthritisen
dc.typeoutro-
dc.contributor.institutionUniv Childrens Hosp-
dc.contributor.institutionUniv Munster-
dc.contributor.institutionPaediat Rheumatol Int Trials Org-
dc.contributor.institutionChildrens Hosp Datteln-
dc.contributor.institutionWilhelmina Childrens Hosp-
dc.contributor.institutionInst Child Hlth UCL-
dc.contributor.institutionRambam Med Ctr-
dc.contributor.institutionHop Cochin-
dc.contributor.institutionInst Portugues Reumatol-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionAzienda Osped-
dc.contributor.institutionHosp Pediat Juan P Garrahan-
dc.contributor.institutionUniv Genoa-
dc.description.affiliationUniv Childrens Hosp, Munster, Germany-
dc.description.affiliationUniv Munster, D-48149 Munster, Germany-
dc.description.affiliationPaediat Rheumatol Int Trials Org, Ist Giannina Gaslini, Genoa, Italy-
dc.description.affiliationChildrens Hosp Datteln, Datteln, Germany-
dc.description.affiliationWilhelmina Childrens Hosp, Utrecht, Netherlands-
dc.description.affiliationInst Child Hlth UCL, London, England-
dc.description.affiliationRambam Med Ctr, Haifa, Israel-
dc.description.affiliationHop Cochin, Ctr Reference Natl Arthrites Juveniles, F-75674 Paris, France-
dc.description.affiliationInst Portugues Reumatol, Lisbon, Portugal-
dc.description.affiliationUNESP, Botucatu, SP, Brazil-
dc.description.affiliationAzienda Osped, Sciacca, Ag, Italy-
dc.description.affiliationHosp Pediat Juan P Garrahan, Buenos Aires, DF, Argentina-
dc.description.affiliationUniv Genoa, Genoa, Italy-
dc.description.affiliationUnespUNESP, Botucatu, SP, Brazil-
dc.description.sponsorshipIdInterdisciplinary Centre of Clinical Research at the University of Munster (IZKF)CRA04-
dc.description.sponsorshipIdSparks08ICH09-
dc.description.sponsorshipIdEuropean UnionEC-GA 305266 MIAMI-
dc.identifier.doi10.1002/acr.22248-
dc.identifier.wosWOS:000337975700020-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofArthritis Care & Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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