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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/112170
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dc.contributor.authorRocha, V. A.-
dc.contributor.authorFrazao, R.-
dc.contributor.authorCampos, L. M. G.-
dc.contributor.authorMello, P.-
dc.contributor.authorDonato, J.-
dc.contributor.authorCruz-Rizzolo, R. J.-
dc.contributor.authorNogueira, M. I.-
dc.contributor.authorPinato, Luciana-
dc.date.accessioned2014-12-03T13:10:29Z-
dc.date.accessioned2016-10-25T20:10:35Z-
dc.date.available2014-12-03T13:10:29Z-
dc.date.available2016-10-25T20:10:35Z-
dc.date.issued2014-01-16-
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2013.10.037-
dc.identifier.citationBrain Research. Amsterdam: Elsevier Science Bv, v. 1543, p. 65-72, 2014.-
dc.identifier.issn0006-8993-
dc.identifier.urihttp://hdl.handle.net/11449/112170-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/112170-
dc.description.abstractThe suprachiasmatic nucleus (SCN), which is the main circadian biological clock in mammals, is composed of multiple cells that function individually as independent oscillators to express the self-sustained mRNA and protein rhythms of the so-called clock genes. Knowledge regarding the presence and localization of the proteins and neuroactive substances of the SCN are essential for understanding this nucleus and for its successful manipulation. Although there have been advances in the investigation of the intrinsic organization of the SCN in rodents, little information is available in diurnal species, especially in primates. This study, which explores the pattern of expression and localization of PER2 protein in the SCN of capuchin monkey, evaluates aspects of the circadian system that are common to both primates and rodents. Here, we showed that PER2 protein immunoreactivity is higher during the light phase. Additionally, the complex organization of cells that express vasopressin, vasoactive intestinal polypeptide, neuron-specific nuclear protein, calbindin and calretinin in the SCN, as demonstrated by their immunoreactivity, reveals an intricate network that may be related to the similarities and differences reported between rodents and primates in the literature. (C) 2013 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent65-72-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectBiological rhythmsen
dc.subjectDiurnal monkeyen
dc.subjectNeuroanatomyen
dc.subjectPer2en
dc.titleIntrinsic organization of the suprachiasmatic nucleus in the capuchin monkeyen
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Anat, BR-05508 Sao Paulo, Brazil-
dc.description.affiliationSao Paulo State Univ, Dept Speech Language & Hearing Therapy, BR-17515901 Marilia, SP, Brazil-
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508 Sao Paulo, Brazil-
dc.description.affiliationSao Paulo State Univ Aracatuba, Dept Basic Sci, Aracatuba, SP, Brazil-
dc.description.affiliationUnespSao Paulo State Univ, Dept Speech Language & Hearing Therapy, BR-17515901 Marilia, SP, Brazil-
dc.description.affiliationUnespSao Paulo State Univ Aracatuba, Dept Basic Sci, Aracatuba, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 08/53689-8-
dc.identifier.doi10.1016/j.brainres.2013.10.037-
dc.identifier.wosWOS:000330491300008-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofBrain Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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