Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/112199
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ronchi, Carlos Fernando | - |
dc.contributor.author | Ferreira, Ana Lúcia dos Anjos | - |
dc.contributor.author | Campos, Fabio Joly | - |
dc.contributor.author | Kurokawa, Cilmery Suemi | - |
dc.contributor.author | Carpi, Mario Ferreira | - |
dc.contributor.author | Moraes, Marcos Aurelio | - |
dc.contributor.author | Bonatto, Rossano César | - |
dc.contributor.author | Yeum, Kyung-Jin | - |
dc.contributor.author | Fioretto, José Roberto | - |
dc.date.accessioned | 2014-12-03T13:10:30Z | - |
dc.date.accessioned | 2016-10-25T20:10:38Z | - |
dc.date.available | 2014-12-03T13:10:30Z | - |
dc.date.available | 2016-10-25T20:10:38Z | - |
dc.date.issued | 2014-01-01 | - |
dc.identifier | http://dx.doi.org/10.1016/j.resp.2013.10.008 | - |
dc.identifier.citation | Respiratory Physiology & Neurobiology. Amsterdam: Elsevier Science Bv, v. 190, n. 1, p. 118-123, 2014. | - |
dc.identifier.issn | 1569-9048 | - |
dc.identifier.uri | http://hdl.handle.net/11449/112199 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/112199 | - |
dc.description.abstract | To compare conventional mechanical ventilation (CMV) and high-frequency oscillatory ventilation (HFOV), with/without inhaled nitric oxide (iNO), for oxygenation, inflammation, antioxidant/oxidative stress status, and DNA damage in a model of acute lung injury (ALI). Lung injury was induced by tracheal infusion of warm saline. Rabbits were ventilated at F-IO2 1.0 and randomly assigned to one of five groups. Overall antioxidant defense/oxidative stress was assessed by total antioxidant performance assay, and DNA damage by comet assay. Ventilatory and hemodynamic parameters were recorded every 30 min for 4 h. ALI groups showed worse oxygenation than controls after lung injury. After 4 h of mechanical ventilation, HFOV groups presented significant improvements in oxygenation. HFOV with and without iNO, and CMV with iNO showed significantly increased antioxidant defense and reduced DNA damage than CMV without iNO. Inhaled nitric oxide did not beneficially affect HFOV in relation to antioxidant defense/oxidative stress and pulmonary DNA damage. Overall, lung injury was reduced using HFOV or CMV with iNO. (C) 2013 Elsevier B.V. All rights reserved. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | U.S. Department of Agriculture, Agricultural Research Service | - |
dc.format.extent | 118-123 | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.source | Web of Science | - |
dc.subject | Conventional mechanical ventilation | en |
dc.subject | DNA damage | en |
dc.subject | High-frequency oscillatory ventilation | en |
dc.subject | Inhaled nitric oxide | en |
dc.subject | Pulmonary oxidative stress | en |
dc.title | Interactive effects of mechanical ventilation, inhaled nitric oxide and oxidative stress in acute lung injury | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Tufts Univ | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.description.affiliation | Sao Paulo State Univ, UNESP, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil | - |
dc.description.affiliation | Sao Paulo State Univ, UNESP, Botucatu Med Sch, Dept Pediat, Botucatu, SP, Brazil | - |
dc.description.affiliation | Tufts Univ, Jean Mayer USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA | - |
dc.description.affiliation | Univ Sagrado Coracao, Dept Hlth Sci, BR-17011160 Bauru, SP, Brazil | - |
dc.description.affiliationUnesp | Sao Paulo State Univ, UNESP, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil | - |
dc.description.affiliationUnesp | Sao Paulo State Univ, UNESP, Botucatu Med Sch, Dept Pediat, Botucatu, SP, Brazil | - |
dc.description.sponsorshipId | FAPESP: 08/08199-2 | - |
dc.description.sponsorshipId | U.S. Department of Agriculture, Agricultural Research ServiceUSDA: 58-1950-7-07 | - |
dc.identifier.doi | 10.1016/j.resp.2013.10.008 | - |
dc.identifier.wos | WOS:000329004900017 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Respiratory Physiology & Neurobiology | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.