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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/11226
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dc.contributor.authorCarvalho, Robson Francisco-
dc.contributor.authorDariolli, Rafael-
dc.contributor.authorJustulin Junior, Luis Antonio-
dc.contributor.authorSugizaki, Mario Mateus-
dc.contributor.authorOkoshi, Marina Politi-
dc.contributor.authorCicogna, Antonio Carlos-
dc.contributor.authorFelisbino, Sergio Luis-
dc.contributor.authorDal Pai-Silva, Maeli-
dc.date.accessioned2014-05-20T13:32:52Z-
dc.date.accessioned2016-10-25T16:51:05Z-
dc.date.available2014-05-20T13:32:52Z-
dc.date.available2016-10-25T16:51:05Z-
dc.date.issued2006-12-01-
dc.identifierhttp://dx.doi.org/10.1111/j.1365-2613.2006.00497.x-
dc.identifier.citationInternational Journal of Experimental Pathology. Oxford: Blackwell Publishing, v. 87, n. 6, p. 437-443, 2006.-
dc.identifier.issn0959-9673-
dc.identifier.urihttp://hdl.handle.net/11449/11226-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/11226-
dc.description.abstractHeart failure is associated with a skeletal muscle myopathy with cellular and extracellular alterations. The hypothesis of this investigation is that extracellular changes may be associated with enhanced mRNA expression and activity of matrix metalloproteinases (MMP). We examined MMP mRNA expression and MMP activity in Soleus (SOL), extensor digitorum longus (EDL), and diaphragm (DIA) muscles of young Wistar rat with monocrotaline-induced heart failure. Rats injected with saline served as age-matched controls. MMP2 and MMP9 mRNA contents were determined by RT-PCR and MMP activity by electrophoresis in gelatin-containing polyacrylamide gels in the presence of SDS under non-reducing conditions. Heart failure increased MMP9 mRNA expression and activity in SOL, EDL and DIA and MMP2 mRNA expression in DIA. These results suggest that MMP changes may contribute to the skeletal muscle myopathy during heart failure.en
dc.format.extent437-443-
dc.language.isoeng-
dc.publisherBlackwell Publishing-
dc.sourceWeb of Science-
dc.subjectextracellular matrixpt
dc.subjectheart failurept
dc.subjectmetalloproteinasespt
dc.subjectskeletal musclept
dc.subjectWistar ratspt
dc.titleHeart failure alters matrix metalloproteinase gene expression and activity in rat skeletal muscleen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Dept Morphol, BR-18618000 Botucatu, SP, Brazil-
dc.description.affiliationUniv Estadual Campinas, Dept Biol Celular, Campinas, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Dept Clin Med, Botucatu, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Dept Morphol, BR-18618000 Botucatu, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Dept Clin Med, Botucatu, SP, Brazil-
dc.identifier.doi10.1111/j.1365-2613.2006.00497.x-
dc.identifier.wosWOS:000242221900004-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofInternational Journal of Experimental Pathology-
dc.identifier.orcid0000-0002-4901-7714pt
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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