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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/112423
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dc.contributor.authorMessora, Michel R.-
dc.contributor.authorOliveira, Luiz F. F.-
dc.contributor.authorFoureaux, Renata C.-
dc.contributor.authorTaba, Mario-
dc.contributor.authorZangeronimo, Marcio G.-
dc.contributor.authorFurlaneto, Flavia A. C.-
dc.contributor.authorPereira, Luciano J.-
dc.date.accessioned2014-12-03T13:10:42Z-
dc.date.accessioned2016-10-25T20:11:09Z-
dc.date.available2014-12-03T13:10:42Z-
dc.date.available2016-10-25T20:11:09Z-
dc.date.issued2013-12-01-
dc.identifierhttp://dx.doi.org/10.1902/jop.2013.120644-
dc.identifier.citationJournal Of Periodontology. Chicago: Amer Acad Periodontology, v. 84, n. 12, p. 1818-1826, 2013.-
dc.identifier.issn0022-3492-
dc.identifier.urihttp://hdl.handle.net/11449/112423-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/112423-
dc.description.abstractBackground: With increase in the incidence of resistance to antibiotics, probiotics are emerging as a promising adjunctive periodontal therapy. The authors of this study evaluate the influence of probiotic (PROB) supplementation on ligature-induced periodontitis (LIP) and intestinal morphology in rats.Methods: Thirty-two rats were randomly divided into four groups: control (C), LIP, PROB, and LIP/PROB. In groups PROB and LIP/PROB, the PROB was administered orally by addition to the drinking water of the animals for 44 days. In groups LIP and LIP/PROB, the mandibular right first molar of the animals received a cotton ligature that was left in the same position for 14 days. All animals were euthanized 44 days after the start of the PROB supplementation. The jaws were resected and histomorphometric analyses were performed. The measurements included evaluation of attachment loss (AL) and alveolar bone level (ABL) on the distal root of the mandibular first molar. Samples of the duodenum, jejunum, and ileum were also dissected from each animal to evaluate the villous height (VH) and crypt depth (CD). The data obtained were subjected to statistical analyses (analysis of variance, Tukey; P <0.05).Results: Mean values of AL and ABL were significantly higher in group LIP compared with group LIP/PROB (AL: 3.05 +/- 0.57 mm and 1.78 +/- 0.63 mm, respectively; ABL: 4.21 +/- 0.42 mm and 3.38 +/- 0.17 mm, respectively). In group LIP/PROB, the mean values of VH and CD of the jejunum were significantly higher than the ones from group LIP (VH: 672.1 +/- 83.3 mu m and 528.0 +/- 51.7 mu m, respectively; CD: 463.8 +/- 100.9 mu m and 269.0 +/- 48.4 mu m, respectively).Conclusions: It can be concluded that PROB supplementation 1) reduces AL and alveolar bone loss in rats with LIP and 2) can protect the small intestine from reactive changes induced by LIP.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent1818-1826-
dc.language.isoeng-
dc.publisherAmer Acad Periodontology-
dc.sourceWeb of Science-
dc.subjectAlveolar bone lossen
dc.subjectBacillus subtilisen
dc.subjectintestinal mucosaen
dc.subjectperiodontitisen
dc.subjectprobioticsen
dc.subjectratsen
dc.titleProbiotic Therapy Reduces Periodontal Tissue Destruction and Improves the Intestinal Morphology in Rats With Ligature-Induced Periodontitisen
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionLavras Univ Ctr-
dc.contributor.institutionUniversidade Federal de Lavras (UFLA)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Sao Paulo, Sch Dent Ribeirao Preto, Dept Oral & Maxillofacial Surg & Periodontol, BR-14040904 Sao Paulo, Brazil-
dc.description.affiliationLavras Univ Ctr, Sch Dent, Lavras, MG, Brazil-
dc.description.affiliationUniv Fed Lavras, Dept Physiol & Pharmacol, Lavras, MG, Brazil-
dc.description.affiliationSao Paulo State Univ, Dent Sch Aracatuba, Dept Surg & Integrated Clin, Div Periodont, Sao Paulo, Brazil-
dc.description.affiliationUnespSao Paulo State Univ, Dent Sch Aracatuba, Dept Surg & Integrated Clin, Div Periodont, Sao Paulo, Brazil-
dc.description.sponsorshipIdCNPq: 475468/2010-4-
dc.identifier.doi10.1902/jop.2013.120644-
dc.identifier.wosWOS:000328686300016-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Periodontology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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