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dc.contributor.authorGasperin, Bernardo G.-
dc.contributor.authorFerreira, Rogerio-
dc.contributor.authorRovani, Monique T.-
dc.contributor.authorBordignon, Vilceu-
dc.contributor.authorDuggavathi, Raj-
dc.contributor.authorBuratini, Jose-
dc.contributor.authorOliveira, Joao F. C.-
dc.contributor.authorGoncalves, Paulo B. D.-
dc.identifier.citationAnimal Reproduction Science. Amsterdam: Elsevier Science Bv, v. 144, n. 3-4, p. 72-78, 2014.-
dc.description.abstractBone morphogenetic proteins are known to be involved in determining ovulation rate in mammals. The mechanisms through which these proteins determine follicle fate are incompletely understood. In the present study, we used cattle as a model to evaluate the regulation of BMP15 and GDF9 receptors in granulosa cells during dominant follicle (DF) selection. Before follicular deviation (day 2 of the follicular wave), BMPR2 mRNA abundance tended to be higher in the second largest follicles (F2; P < 0.1) compared to the future dominant follicle (F1). At the expected time of follicular deviation (day 3), BMPR2 and BMPR1B mRNA levels were higher in subordinate follicles (SFs; P < 0.05) compared to dominant follicles (DFs). After deviation (on day 4), BMPR1B mRNA and protein were significantly more abundant in atretic SFs (as assessed by cleaved caspase 3) than in DFs. The fact that BMPR1B is more expressed in atretic follicles was further confirmed by using intrafollicular treatment with two agents known to induce atresia, namely an estradiol receptor antagonist (fulvestrant) and FGF10. In conclusion, the fact that BMPR-1B and -2 are more expressed in the second largest follicles before and at the expected time of follicular deviation is indicative of their inhibitory role in follicle differentiation and steroidogenesis. BMPR1B also seems to have a pivotal role during follicle regression since it is upregulated in advanced atretic follicles. (C) 2013 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectFollicle deviationen
dc.titleExpression of receptors for BMP15 is differentially regulated in dominant and subordinate follicles during follicle deviation in cattleen
dc.contributor.institutionUniversidade Federal de Sergipe (UFS)-
dc.contributor.institutionSanta Catarina State Univ-
dc.contributor.institutionMcGill Univ-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Fed Santa Maria, Lab Biotechnol & Anim Reprod BioRep, BR-97105900 Santa Maria, RS, Brazil-
dc.description.affiliationSanta Catarina State Univ, Dept Anim Sci, Chapeco, SC, Brazil-
dc.description.affiliationMcGill Univ, Dept Anim Sci, Ste Anne De Bellevue, PQ, Canada-
dc.description.affiliationSao Paulo State Univ, Inst Biosci, Dept Physiol, Botucatu, SP, Brazil-
dc.description.affiliationUnespSao Paulo State Univ, Inst Biosci, Dept Physiol, Botucatu, SP, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofAnimal Reproduction Science-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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