You are in the accessibility menu

Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGoncalves Zorzella-Pezavento, Sofia Fernanda-
dc.contributor.authorFujiara Guerino, Clara Pires-
dc.contributor.authorChiuso-Minicucci, Fernanda-
dc.contributor.authorDonega Franca, Thais Graziela-
dc.contributor.authorWatanabe Ishikawa, Larissa Lumi-
dc.contributor.authorMasson, Ana Paula-
dc.contributor.authorSilva, Celio Lopes-
dc.contributor.authorSartori, Alexandrina-
dc.identifier.citationClinical & Developmental Immunology. New York: Hindawi Publishing Corporation, 9 p., 2013.-
dc.description.abstractA prime-boost strategy conserving BCG is considered the most promising vaccine to control tuberculosis. A boost with a DNA vaccine containing the mycobacterial gene of a heat shock protein (pVAXhsp65) after BCG priming protected mice against experimental tuberculosis. However, anti-hsp65 immunity could worsen an autoimmune disease due to molecular mimicry. In this investigation, we evaluated the effect of a previous BCG or BCG/pVAXhsp65 immunization on experimental autoimmune encephalomyelitis (EAE) development. Female Lewis rats were immunized with BCG or BCG followed by pVAXhsp65 boosters. The animals underwent EAE induction and were daily evaluated for weight loss and clinical score. They were euthanized during recovery phase to assess immune response and inflammatory infiltration at the central nervous system. Previous immunization did not aggravate or accelerate clinical score or weight loss. In addition, this procedure clearly decreased inflammation in the brain. BCG immunization modulated the host immune response by triggering a significant reduction in IL-10 and IFN-gamma levels induced by myelin basic protein. These data indicated that vaccination protocols with BCG or BCG followed by boosters with pVAXhsp65 did not trigger a deleterious effect on EAE evolution.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.publisherHindawi Publishing Corporation-
dc.sourceWeb of Science-
dc.titleBCG and BCG/DNAhsp65 Vaccinations Promote Protective Effects without Deleterious Consequences for Experimental Autoimmune Encephalomyelitisen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationUniv Estadual Paulista UNESP, Inst Biociencias, Dept Microbiol & Imunol, BR-18618970 Botucatu, SP, Brazil-
dc.description.affiliationUniv Sao Paulo, Dept Bioquim & Imunol, BR-14049900 Ribeirao Preto, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Inst Biociencias, Dept Microbiol & Imunol, BR-18618970 Botucatu, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 07/05353-8-
dc.description.sponsorshipIdCNPq: 473351/2004-8-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofClinical & Developmental Immunology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.