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- Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats
- Universidade Estadual Paulista (UNESP)
- Universidade de São Paulo (USP)
- Universidade Estadual de Campinas (UNICAMP)
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
- FAPESP: 10/17262-0
- FAPESP: 11/01954-2
- FAPESP: 10/14110-4
- CNPq: 471646/2011-3
- Bisphenol A (BPA) is a chemical that has been investigated for it potential to cause prostate diseases. In this study, pregnant Sprague-Dawley rats were treated with 25 or 250 mu g/kg BPA from gestational day (GD) 10 to GD21 with or without concurrent indole-3-carbinol (I3C) feeding. I3C is a phytochemical, and it affords chemoprotection against many types of neoplasia. Male F1 rats from different litters were euthanized on post-natal day (PND) 21 and PND180. BPA-treated groups showed a significant increase in histopathological lesions, but I3C feeding reversed many of these changes, mainly at PND180. Maternal I3C feeding increased prostate epithelial apoptosis in the BPA-treated groups and across age groups. Furthermore, I3C induced partial normalization of the prostate histoarchitecture. The results pointed to a protective effect of maternal I3C feeding during pregnancy in the BPA-exposed male offspring, thereby indicating reduction in the harmful effects of gestational BPA imprinting on the prostate. (C) 2013 Elsevier Inc. All rights reserved.
- Reproductive Toxicology. Oxford: Pergamon-elsevier Science Ltd, v. 43, p. 56-66, 2014.
- Elsevier B.V.
- Bisphenol A
- Reproductive toxicology
- Acesso restrito
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