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dc.contributor.authorBrandt, Joyce Zalotti-
dc.contributor.authorSilveira, Livia Teresa R.-
dc.contributor.authorGrassi, Tony Fernando-
dc.contributor.authorAnselmo-Franci, Janete A.-
dc.contributor.authorFavaro, Wagner Jose-
dc.contributor.authorFelisbino, Sergio Luis-
dc.contributor.authorBarbisan, Luis Fernando-
dc.contributor.authorScarano, Wellerson Rodrigo-
dc.identifier.citationReproductive Toxicology. Oxford: Pergamon-elsevier Science Ltd, v. 43, p. 56-66, 2014.-
dc.description.abstractBisphenol A (BPA) is a chemical that has been investigated for it potential to cause prostate diseases. In this study, pregnant Sprague-Dawley rats were treated with 25 or 250 mu g/kg BPA from gestational day (GD) 10 to GD21 with or without concurrent indole-3-carbinol (I3C) feeding. I3C is a phytochemical, and it affords chemoprotection against many types of neoplasia. Male F1 rats from different litters were euthanized on post-natal day (PND) 21 and PND180. BPA-treated groups showed a significant increase in histopathological lesions, but I3C feeding reversed many of these changes, mainly at PND180. Maternal I3C feeding increased prostate epithelial apoptosis in the BPA-treated groups and across age groups. Furthermore, I3C induced partial normalization of the prostate histoarchitecture. The results pointed to a protective effect of maternal I3C feeding during pregnancy in the BPA-exposed male offspring, thereby indicating reduction in the harmful effects of gestational BPA imprinting on the prostate. (C) 2013 Elsevier Inc. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectBisphenol Aen
dc.subjectReproductive toxicologyen
dc.titleIndole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 ratsen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.description.affiliationSao Paulo State Univ, Inst Biosci, Dept Morphol, UNESP, BR-18618970 Botucatu, SP, Brazil-
dc.description.affiliationUNESP, Sch Med, Dept Pathol, BR-18618970 Botucatu, SP, Brazil-
dc.description.affiliationUniv Sao Paulo FORP USP, Fac Dent, BR-14040904 Ribeirao Preto, SP, Brazil-
dc.description.affiliationUniv Estadual Campinas, UNICAMP, Inst Biol, BR-13083862 Campinas, SP, Brazil-
dc.description.affiliationUnespSao Paulo State Univ, Inst Biosci, Dept Morphol, UNESP, BR-18618970 Botucatu, SP, Brazil-
dc.description.affiliationUnespUNESP, Sch Med, Dept Pathol, BR-18618970 Botucatu, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 10/17262-0-
dc.description.sponsorshipIdFAPESP: 11/01954-2-
dc.description.sponsorshipIdFAPESP: 10/14110-4-
dc.description.sponsorshipIdCNPq: 471646/2011-3-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofReproductive Toxicology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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