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http://acervodigital.unesp.br/handle/11449/112708
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DC Field | Value | Language |
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dc.contributor.author | Santos, Keity Souza | - |
dc.contributor.author | Stephano, Marco Antonio | - |
dc.contributor.author | Marcelino, Jose Roberto | - |
dc.contributor.author | Resende Ferreira, Virginia Maria | - |
dc.contributor.author | Rocha, Thalita | - |
dc.contributor.author | Caricati, Celso | - |
dc.contributor.author | Higashi, Hisako Gondo | - |
dc.contributor.author | Moro, Ana Maria | - |
dc.contributor.author | Kalil, Jorge Elias | - |
dc.contributor.author | Malaspina, Osmar | - |
dc.contributor.author | Morato Castro, Fabio Fernandes | - |
dc.contributor.author | Palma, Mario Sergio | - |
dc.date.accessioned | 2014-12-03T13:11:00Z | - |
dc.date.accessioned | 2016-10-25T20:11:49Z | - |
dc.date.available | 2014-12-03T13:11:00Z | - |
dc.date.available | 2016-10-25T20:11:49Z | - |
dc.date.issued | 2013-11-13 | - |
dc.identifier | http://dx.doi.org/10.1371/journal.pone.0079971 | - |
dc.identifier.citation | Plos One. San Francisco: Public Library Science, v. 8, n. 11, 10 p., 2013. | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/11449/112708 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/112708 | - |
dc.description.abstract | Victims of massive bee attacks become extremely ill, presenting symptoms ranging from dizziness and headache to acute renal failure and multiple organ failure that can lead to death. Previous attempts to develop specific antivenom to treat these victims have been unsuccessful. We herein report a F(ab)'(2)-based antivenom raised in horse as a potential new treatment for victims of multiple bee stings. The final product contains high specific IgG titers and is effective in neutralizing toxic effects, such as hemolysis, cytotoxicity and myotoxicity. The assessment of neutralization was revised and hemolysis, the primary toxic effect of these stings, was fully neutralized in vivo for the first time. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.description.sponsorship | FINEP (CT-BIOTEC-Anticorpos -MCTFINEP) | - |
dc.description.sponsorship | Butantan Institute | - |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
dc.format.extent | 10 | - |
dc.language.iso | eng | - |
dc.publisher | Public Library Science | - |
dc.source | Web of Science | - |
dc.title | Production of the First Effective Hyperimmune Equine Serum Antivenom against Africanized Bees | en |
dc.type | outro | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.contributor.institution | Inst Invest Immunol INCT | - |
dc.contributor.institution | Instituto Butantan | - |
dc.contributor.institution | Univ Sao Francisco | - |
dc.contributor.institution | Inst Technol Parana | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Univ Sao Paulo, Sch Med, FMUSP, Div Clin Immunol & Allergy, Sao Paulo, Brazil | - |
dc.description.affiliation | Inst Invest Immunol INCT, Sao Paulo, Brazil | - |
dc.description.affiliation | Univ Sao Paulo, Fac Ciencias Farmaceut, Sao Paulo, Brazil | - |
dc.description.affiliation | Butantan Inst, Div Hyperimmune Plasmas, Sao Paulo, Brazil | - |
dc.description.affiliation | Univ Sao Francisco, Sch Med, BR-12900000 Braganca Paulista, SP, Brazil | - |
dc.description.affiliation | Butantan Inst, Special Pilot Lab Res & Dev Vet Immunobiol, Sao Paulo, Brazil | - |
dc.description.affiliation | Inst Technol Parana, Curitiba, Parana, Brazil | - |
dc.description.affiliation | Butantan Inst, Lab Biopharmaceut Anim Cells, Sao Paulo, Brazil | - |
dc.description.affiliation | Univ Sao Paulo, Sch Med, Heart Inst InCor, LIM 19, Sao Paulo, Brazil | - |
dc.description.affiliation | Univ Sao Paulo State UNESP, Ctr Study Social Insects, Inst Biosci, Dept Biol, Rio Claro, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Sao Paulo State UNESP, Ctr Study Social Insects, Inst Biosci, Dept Biol, Rio Claro, SP, Brazil | - |
dc.description.sponsorshipId | FAPESP: 11/51684-1 | - |
dc.identifier.doi | 10.1371/journal.pone.0079971 | - |
dc.identifier.wos | WOS:000327254700167 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.identifier.file | WOS000327254700167.pdf | - |
dc.relation.ispartof | PLOS ONE | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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