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dc.contributor.authorMateron, Elsa M.-
dc.contributor.authorHuang, Po-Jung Jimmy-
dc.contributor.authorWong, Ademar-
dc.contributor.authorPupim Ferreira, Antonio A.-
dc.contributor.authorTaboada Sotomayor, Maria Del Pilar-
dc.contributor.authorLiu, Juewen-
dc.date.accessioned2014-12-03T13:11:28Z-
dc.date.accessioned2016-10-25T20:14:18Z-
dc.date.available2014-12-03T13:11:28Z-
dc.date.available2016-10-25T20:14:18Z-
dc.date.issued2014-08-15-
dc.identifierhttp://dx.doi.org/10.1016/j.bios.2014.02.070-
dc.identifier.citationBiosensors & Bioelectronics. Oxford: Elsevier Advanced Technology, v. 58, p. 232-236, 2014.-
dc.identifier.issn0956-5663-
dc.identifier.urihttp://hdl.handle.net/11449/113180-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/113180-
dc.description.abstractWith the fast growth of cancer research, new analytical methods are needed to measure anticancer drugs. This is usually accomplished by using sophisticated analytical instruments. Biosensors are attractive candidates for measuring anticancer drugs, but currently few biosensors can achieve this goal. In particular, it is challenging to have a general method to monitor various types of anticancer drugs with different structures. In this work, a biosensor was developed to detect anticancer drugs by modifying carbon paste electrodes with glutathione-s-transferase (GST) enzymes. GST is widely studied in the metabolism of xenobiotics and is a major contributing factor in resistance to anticancer drugs. The measurement of anticancer drugs is based on competition between 1-chloro-2,4-dinitrobenzene (CDNB) and the drugs for the GST enzyme in the electrochemical potential at 0.1 V vs. Ag/AgCl by square wave voltammetry (SWV) or using a colorimetric method. The sensor shows a detection limit of 8.8 mu M cisplatin and exhibits relatively long life time in daily measurements. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipUniversity of Waterloo-
dc.description.sponsorshipNSERC-
dc.description.sponsorshipEmerging Leaders in the Americas Program (ELAP) from the Canadian government-
dc.format.extent232-236-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectGlutathione-s-transferaseen
dc.subjectCarbon past electrodeen
dc.subjectCisplatinen
dc.subjectGlutathioneen
dc.titleGlutathione-s-transferase modified electrodes for detecting anticancer drugsen
dc.typeoutro-
dc.contributor.institutionUniv Waterloo-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Waterloo, Dept Chem, Waterloo, ON N2L 3G1, Canada-
dc.description.affiliationUniv Waterloo, Waterloo Inst Nanotechnol, Waterloo, ON N2L 3G1, Canada-
dc.description.affiliationState Univ Sao Paulo UNESP, Inst Chem, Dept Analyt Chem, BR-14801970 Araraquara, SP, Brazil-
dc.description.affiliationUnespState Univ Sao Paulo UNESP, Inst Chem, Dept Analyt Chem, BR-14801970 Araraquara, SP, Brazil-
dc.identifier.doi10.1016/j.bios.2014.02.070-
dc.identifier.wosWOS:000336109900036-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofBiosensors & Bioelectronics-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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