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Campo DC | Valor | Idioma |
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dc.contributor.author | Andrade, Telma Gonçalves Carneiro Spera de | - |
dc.contributor.author | Zangrossi, Helio | - |
dc.contributor.author | Graeff, Frederico G. | - |
dc.date.accessioned | 2014-12-03T13:11:37Z | - |
dc.date.accessioned | 2016-10-25T20:14:40Z | - |
dc.date.available | 2014-12-03T13:11:37Z | - |
dc.date.available | 2016-10-25T20:14:40Z | - |
dc.date.issued | 2013-12-01 | - |
dc.identifier | http://dx.doi.org/10.1177/0269881113499208 | - |
dc.identifier.citation | Journal Of Psychopharmacology. London: Sage Publications Ltd, v. 27, n. 12, p. 1107-1115, 2013. | - |
dc.identifier.issn | 0269-8811 | - |
dc.identifier.uri | http://hdl.handle.net/11449/113338 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/113338 | - |
dc.description.abstract | Although the role of the median raphe nucleus (MRN) in the regulation of anxiety has received less attention than that of the dorsal raphe nucleus (DRN) there is substantial evidence supporting this function. Reported results with different animal models of anxiety in rats show that whereas inactivation of serotonergic neurons in the MRN causes anxiolysis, the stimulation of the same neurons is anxiogenic. In particular, studies using the elevated T-maze comparing serotonergic interventions in the MRN and in the DRN indicate that the former affect only the inhibitory avoidance task, which has been related to generalized anxiety. In contrast, similar operations in the DRN change both the inhibitory avoidance and the one-way escape task, the latter being representative of panic disorder. Simultaneous injections of 5-HT-acting drugs in the MRN and in the dorsal hippocampus (DH) suggest that the MRN-DH pathway mediates the regulatory function of the MRN in anxiety. Overall, the results discussed in this review point to a relevant role of the MRN in the regulation of anxiety, but not panic, through the 5-HT pathway that innervates the DH. | en |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.description.sponsorship | Fundacao de Amparo ao Ensino, Pesquisa e Assistencia do Hospital das Clinicas de Ribeirao Preto (FAEPA) | - |
dc.format.extent | 1107-1115 | - |
dc.language.iso | eng | - |
dc.publisher | Sage Publications Ltd | - |
dc.source | Web of Science | - |
dc.subject | Median raphe nucleus | en |
dc.subject | dorsal raphe nucleus | en |
dc.subject | hippocampus | en |
dc.subject | serotonin | en |
dc.subject | anxiety and panic | en |
dc.title | The median raphe nucleus in anxiety revisited | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.contributor.institution | Inst Neurosci & Behav INeC | - |
dc.description.affiliation | Sao Paulo State Univ, UNESP, Dept Biol Sci, Assis, Brazil | - |
dc.description.affiliation | Univ Sao Paulo, Dept Pharmacol, BR-14049 Ribeirao Preto, Brazil | - |
dc.description.affiliation | Univ Sao Paulo, Sch Med Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil | - |
dc.description.affiliation | Inst Neurosci & Behav INeC, Ribeirao Preto, Brazil | - |
dc.description.affiliationUnesp | Sao Paulo State Univ, UNESP, Dept Biol Sci, Assis, Brazil | - |
dc.description.sponsorshipId | FAEPA: 05/11 | - |
dc.identifier.doi | 10.1177/0269881113499208 | - |
dc.identifier.wos | WOS:000326859700005 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Journal of Psychopharmacology | - |
Aparece nas coleções: | Artigos, TCCs, Teses e Dissertações da Unesp |
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