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http://acervodigital.unesp.br/handle/11449/113435
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DC Field | Value | Language |
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dc.contributor.author | Fontana, Carla R. | - |
dc.contributor.author | Lerman, Mark A. | - |
dc.contributor.author | Patel, Niraj | - |
dc.contributor.author | Grecco, Clovis | - |
dc.contributor.author | Souza Costa, Carlos A. de | - |
dc.contributor.author | Amiji, Mansoor M. | - |
dc.contributor.author | Bagnato, Vanderlei S. | - |
dc.contributor.author | Soukos, Nikolaos S. | - |
dc.date.accessioned | 2014-12-03T13:11:42Z | - |
dc.date.accessioned | 2016-10-25T20:14:52Z | - |
dc.date.available | 2014-12-03T13:11:42Z | - |
dc.date.available | 2016-10-25T20:14:52Z | - |
dc.date.issued | 2013-02-01 | - |
dc.identifier | http://dx.doi.org/10.1007/s10103-012-1091-6 | - |
dc.identifier.citation | Lasers In Medical Science. London: Springer London Ltd, v. 28, n. 2, p. 479-486, 2013. | - |
dc.identifier.issn | 0268-8921 | - |
dc.identifier.uri | http://hdl.handle.net/11449/113435 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/113435 | - |
dc.description.abstract | Photodynamic therapy (PDT) is based on the synergism of a photosensitive drug (a photosensitizer) and visible light to destroy target cells (e.g., malignant, premalignant, or bacterial cells). The aim of this study was to investigate the response of normal rat tongue mucosa to PDT following the topical application of hematoporphyrin derivative (PhotogemA (R)), PhotodithazineA (R), methylene blue (MB), and poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with MB. One hundred and thirty three rats were randomly divided in various groups: the PDT groups were treated with the photosensitizers for 10 min followed by exposure to red light. Those in control groups received neither photosensitizer nor light, and they were subjected to light exposure alone or to photosensitizer alone. Fluorescent signals were obtained from tongue tissue immediately after the topical application of photosensitizers and 24 h following PDT. Histological changes were evaluated at baseline and at 1, 3, 7, and 15 days post-PDT treatment. Fluorescence was detected immediately after the application of the photosensitizers, but not 24 h following PDT. Histology revealed intact mucosa in all experimental groups at all evaluation time points. The results suggest that there is a therapeutic window where PDT with PhotogemA (R), PhotodithazineA (R), MB, and MB-loaded PLGA nanoparticles could safely target oral pathogenic bacteria without damaging normal oral tissue. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.format.extent | 479-486 | - |
dc.language.iso | eng | - |
dc.publisher | Springer | - |
dc.source | Web of Science | - |
dc.subject | Photodynamic therapy | en |
dc.subject | Photosensitizers | en |
dc.subject | Histological analysis | en |
dc.subject | Fluorescence | en |
dc.title | Safety assessment of oral photodynamic therapy in rats | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Harvard Univ | - |
dc.contributor.institution | Forsyth Inst | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.contributor.institution | Northeastern University | - |
dc.description.affiliation | Univ Sao Paulo State UNESP, Sch Pharmaceut Sci, Dept Clin Anal, BR-14801960 Araraquara, Sau Paulo, Brazil | - |
dc.description.affiliation | Harvard Univ, Sch Dent Med, Dept Oral Med Infect & Immun, Boston, MA 02115 USA | - |
dc.description.affiliation | Forsyth Inst, Appl Mol Photomed Lab, Boston, MA 02115 USA | - |
dc.description.affiliation | Univ Sao Paulo, Inst Phys Sao Carlos, BR-15980900 Sao Carlos, Sau Paulo, Brazil | - |
dc.description.affiliation | Univ Sao Paulo State UNESP, Dent Sch Araraquara, BR-14801960 Araraquara, Sau Paulo, Brazil | - |
dc.description.affiliation | Northeastern Univ, Bouve Coll Hlth Sci, Sch Pharm, Dept Pharmaceut Sci, Boston, MA 02115 USA | - |
dc.description.affiliationUnesp | Univ Sao Paulo State UNESP, Sch Pharmaceut Sci, Dept Clin Anal, BR-14801960 Araraquara, Sau Paulo, Brazil | - |
dc.description.affiliationUnesp | Univ Sao Paulo State UNESP, Dent Sch Araraquara, BR-14801960 Araraquara, Sau Paulo, Brazil | - |
dc.identifier.doi | 10.1007/s10103-012-1091-6 | - |
dc.identifier.wos | WOS:000315579400018 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Lasers in Medical Science | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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