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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/11410
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dc.contributor.authorBartchewsky, Waldemar-
dc.contributor.authorMartini, Mariana R.-
dc.contributor.authorSquassoni, Aline C.-
dc.contributor.authorAlvarez, Marisa C.-
dc.contributor.authorLadeira, Marcelo S. P.-
dc.contributor.authorSalvadori, Daisy Maria Favero-
dc.contributor.authorTrevisan, Miriam A.-
dc.contributor.authorPedrazzoli, Jose-
dc.contributor.authorRibeiro, Marcelo L.-
dc.date.accessioned2014-05-20T13:33:21Z-
dc.date.accessioned2016-10-25T16:51:26Z-
dc.date.available2014-05-20T13:33:21Z-
dc.date.available2016-10-25T16:51:26Z-
dc.date.issued2010-01-01-
dc.identifierhttp://dx.doi.org/10.1007/s10620-008-0699-7-
dc.identifier.citationDigestive Diseases and Sciences. Dordrecht: Springer, v. 55, n. 1, p. 111-116, 2010.-
dc.identifier.issn0163-2116-
dc.identifier.urihttp://hdl.handle.net/11449/11410-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/11410-
dc.description.abstractThe aim of the present study is to evaluate the influence of Helicobacter pylori on Bax and Bcl-2 mRNA and protein levels in patients with chronic gastritis and gastric cancer. The study included 217 patients, of which 26 were uninfected; 127 had chronic gastritis and were H. pylori-positive, and 64 had gastric cancer. Bacterial genotypes were evaluated by PCR, and the expression values were determined by quantitative real-time PCR and immunohistochemistry. Our data showed that the up-regulationary effects of H. pylori infection on the proapoptotic gene, Bax, were stronger than its induction of Bcl-2; this effect may increase apoptosis in patients with chronic gastritis. In patients with gastric cancer, the up-regulation of the anti-apoptotic gene, Bcl-2, counteracted the pro-apoptotic effects of Bax, leading to a deregulation of apoptosis-associated gene expression, favoring cell proliferation. Thus, the disturbance in Bax and Bcl-2 balance, induced by H. pylori, might be important in gastric cancer development.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent111-116-
dc.language.isoeng-
dc.publisherSpringer-
dc.sourceWeb of Science-
dc.subjectHelicobacter pylorien
dc.subjectGastric canceren
dc.subjectBaxen
dc.subjectBcl-2en
dc.subjectReal-time PCRen
dc.titleEffects of Helicobacter pylori Infection on the Expressions of Bax and Bcl-2 in Patients with Chronic Gastritis and Gastric Canceren
dc.typeoutro-
dc.contributor.institutionUniv Sao Francisco-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionLab MULTIPAT-
dc.description.affiliationUniv Sao Francisco, Unidade Integrada Farmacol & Gastroenterol, BR-12900000 Braganca Paulista, SP, Brazil-
dc.description.affiliationUNESP, Dpto Clin Med, Botucatu, SP, Brazil-
dc.description.affiliationUNESP, Dpto Patol, Botucatu, SP, Brazil-
dc.description.affiliationLab MULTIPAT, Campinas, SP, Brazil-
dc.description.affiliationUnespUNESP, Dpto Clin Med, Botucatu, SP, Brazil-
dc.description.affiliationUnespUNESP, Dpto Patol, Botucatu, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 05/56736-9-
dc.description.sponsorshipIdFAPESP: 06/29925-0-
dc.identifier.doi10.1007/s10620-008-0699-7-
dc.identifier.wosWOS:000273520500018-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofDigestive Diseases and Sciences-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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