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dc.contributor.authorAguiar, Bruno Guedes Alcoforado-
dc.contributor.authorCoelho, Daniela Lemos-
dc.contributor.authorCosta, Dorcas Lamounier-
dc.contributor.authorDrumond, Betânia Paiva-
dc.contributor.authorCoelho, Luiz Felipe Leomil-
dc.contributor.authorFigueiredo, Lívio Carvalho-
dc.contributor.authorZacarias, Danielle Alves-
dc.contributor.authorSilva, Jailthon Carlos Da-
dc.contributor.authorAlonso, Diego Peres-
dc.contributor.authorRibolla, Paulo Eduardo Martins-
dc.contributor.authorIshikawa, Edna Aoba Yassui-
dc.contributor.authorGaído, Samara Belchior-
dc.contributor.authorCosta, Carlos Henrique Nery-
dc.date.accessioned2015-02-02T12:39:13Z-
dc.date.accessioned2016-10-25T20:16:21Z-
dc.date.available2015-02-02T12:39:13Z-
dc.date.available2016-10-25T20:16:21Z-
dc.date.issued2014-10-01-
dc.identifierhttp://dx.doi.org/10.1590/0037-8682-0183-2014-
dc.identifier.citationRevista da Sociedade Brasileira de Medicina Tropical. Sociedade Brasileira de Medicina Tropical - SBMT, v. 47, n. 5, p. 593-598, 2014.-
dc.identifier.issn0037-8682-
dc.identifier.urihttp://hdl.handle.net/11449/114114-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/114114-
dc.description.abstractIntroduction Kala-azar is a disease resulting from infection by Leishmania donovani and Leishmania infantum. Most patients with the disease exhibit prolonged fever, wasting, anemia and hepatosplenomegaly without complications. However, some patients develop severe disease with hemorrhagic manifestations, bacterial infections, jaundice, and edema dyspnea, among other symptoms, followed by death. Among the parasite molecules that might influence the disease severity are the macrophage migration inhibitory factor-like proteins (MIF1 and MIF2) and N-acetylglucosamine-1-phosphotransferase (NAGT), which act in the first step of protein N-glycosylation. This study aimed to determine whether MIF1, MIF2 and NAGT are virulence factors for severe kala-azar. Methods To determine the parasite genotype in kala-azar patients from Northeastern Brazil, we sequenced the NAGT genes of L. infantum from 68 patients as well as the MIF1 and MIF2 genes from 76 different subjects with diverse clinical manifestations. After polymerase chain reaction (PCR), the fragments were sequenced, followed by polymorphism identification. Results The nucleotide sequencing of the 144 amplicons revealed the absence of genetic variability of the NAGT, MIF1 and MIF2 genes between the isolates. The conservation of these genes suggests that the clinical variability of kala-azar does not depend upon these genes. Additionally, this conservation suggests that these genes may be critical for parasite survival. Conclusions NAGT, MIF1 and MIF2 do not alter the severity of kala-azar. NAGT, MIF1 and MIF2 are highly conserved among different isolates of identical species and exhibit potential for use in phylogenetic inferences or molecular diagnosis.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.format.extent593-598-
dc.language.isoeng-
dc.publisherSociedade Brasileira de Medicina Tropical - SBMT-
dc.sourceSciELO-
dc.subjectGenetic diversityen
dc.subjectKala-azaren
dc.subjectVisceral leishmaniasisen
dc.subjectMacrophage inhibition factoren
dc.subjectTropical diseasesen
dc.subjectSingle nucleotide polymorphismen
dc.titleGenes that encodes NAGT, MIF1 and MIF2 are not virulence factors for kala-azar caused by Leishmania infantumen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal do Piauí (UFPI)-
dc.contributor.institutionUniversidade Federal de Juiz de Fora (UFJF)-
dc.contributor.institutionUniversidade Federal de Alfenas (UNIFAL)-
dc.contributor.institutionUniversidade Federal da Paraíba (UFPB)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal do Pará Núcleo de Medicina Tropical Laboratório de Biologia Molecular-
dc.description.affiliationUniversidade Federal do Piauí Instituto de Doenças Tropicais Natan Portella Laboratório de Leishmanioses-
dc.description.affiliationUniversidade Federal de Juiz de Fora Laboratório de Virologia-
dc.description.affiliationUniversidade Federal de Alfenas Laboratório de Vacinas-
dc.description.affiliationUniversidade Federal da Paraíba Sociais e Agrárias Centro de Ciências Humanas-
dc.description.affiliationUniversidade Estadual Paulista Instituto de Biociências Departamento de Parasitologia-
dc.description.affiliationUniversidade Federal do Pará Núcleo de Medicina Tropical Laboratório de Biologia Molecular-
dc.description.affiliationUnespUniversidade Estadual Paulista Instituto de Biociências Departamento de Parasitologia-
dc.identifier.doi10.1590/0037-8682-0183-2014-
dc.identifier.scieloS0037-86822014000500593-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileS0037-86822014000500593.pdf-
dc.relation.ispartofRevista da Sociedade Brasileira de Medicina Tropical-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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