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http://acervodigital.unesp.br/handle/11449/11419
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DC Field | Value | Language |
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dc.contributor.author | Castardeli, Edson | - |
dc.contributor.author | Duarte, Daniella R. | - |
dc.contributor.author | Minicucci, Marcos Ferreira | - |
dc.contributor.author | Gaiolla, Paula Schmidt Azevedo | - |
dc.contributor.author | Matsubara, Beatriz Bojikian | - |
dc.contributor.author | Matsubara, Luiz Shiguero | - |
dc.contributor.author | Campana, Alvaro O. | - |
dc.contributor.author | Paiva, Sergio Alberto Rupp de | - |
dc.contributor.author | Zornoff, Leonardo Antonio Mamede | - |
dc.date.accessioned | 2014-05-20T13:33:22Z | - |
dc.date.accessioned | 2016-10-25T16:51:27Z | - |
dc.date.available | 2014-05-20T13:33:22Z | - |
dc.date.available | 2016-10-25T16:51:27Z | - |
dc.date.issued | 2008-03-01 | - |
dc.identifier | http://www.ncbi.nlm.nih.gov/pubmed/18301351 | - |
dc.identifier.citation | Medical Science Monitor. Albertson: Int Scientific Literature, Inc, v. 14, n. 3, p. BR62-BR66, 2008. | - |
dc.identifier.issn | 1234-1010 | - |
dc.identifier.uri | http://hdl.handle.net/11449/11419 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/11419 | - |
dc.description.abstract | Background: We investigated the effects of length of exposure to tobacco smoke on the cardiac remodeling process induced by exposure to cigarette smoke in rats.Material/Methods: Rats were separated into 4 groups: nonsmoking (NS) 2 (n=25; control animals not exposed to tobacco smoke for 2 months), smoking (S)2 (n=22; rats exposed to smoke from 40 cigarettes/d for 2 months), NS6 (n=18; control animals not exposed to tobacco smoke for 6 months), and S6 (n=25; rats exposed to smoke from 40 cigarettes/d for 6 months). All animals underwent echocardiographic, isolated heart, and morphometric studies. Data were analyzed with a 2-way analysis of variance.Results: No interaction among the variables was found; this suggests that length of exposure to tobacco smoke did not influence the effects of exposure to smoke. Values for left ventricular diastolic diameter/body weight and left atrium/body weight were higher (p=0.023 and p=0.001, respectively) in smoking (S2 and S6) than in nonsmoking animals (NS2 and NS6). Left ventricular mass index was higher (p=0.048) in smoking than in nonsmoking animals. In the isovolumetrically beating ventricle, peak systolic pressure was higher (p=0.034) in smoking than in nonsmoking animals. Significantly higher values were found for left ventricular weight (p=0.017) and right ventricular weight (p=0.001) adjusted for body weight in smoking as opposed to nonsmoking animals. Systolic pressure was higher (p=0.001) in smoking (128 +/- 14 mm Hg) than in nonsmoking animals (112 +/- 11 mm Hg).Conclusions: Length of exposure to cigarette smoke did not influence cardiac remodeling caused by exposure to sm oke in rats. | en |
dc.format.extent | BR62-BR66 | - |
dc.language.iso | eng | - |
dc.publisher | Int Scientific Literature, Inc | - |
dc.source | Web of Science | - |
dc.subject | ventricular function | en |
dc.subject | fibrosis | en |
dc.subject | ventricular dilatation | en |
dc.title | Exposure time and ventricular remodeling induced by tobacco smoke exposure in rats | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | UNESP São Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP São Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil | - |
dc.identifier.wos | WOS:000254101400004 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.relation.ispartof | Medical Science Monitor | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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