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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/11465
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dc.contributor.authorVerdichio-Moraes, Camila Fernanda-
dc.contributor.authorToralles-Pereira, Cecilia-
dc.contributor.authorGrotto, Rejane Maria Tommasini-
dc.contributor.authorSilva, Giovanni Faria-
dc.contributor.authorPardini, Maria Ines de Moura Campos-
dc.date.accessioned2014-05-20T13:33:27Z-
dc.date.accessioned2016-10-25T16:51:31Z-
dc.date.available2014-05-20T13:33:27Z-
dc.date.available2016-10-25T16:51:31Z-
dc.date.issued2009-04-01-
dc.identifierhttp://dx.doi.org/10.1002/jmv.21411-
dc.identifier.citationJournal of Medical Virology. Hoboken: Wiley-liss, v. 81, n. 4, p. 757-759, 2009.-
dc.identifier.issn0146-6615-
dc.identifier.urihttp://hdl.handle.net/11449/11465-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/11465-
dc.description.abstractStudies have suggested that hepatitis C virus (HCV) may infect not only hepatocytes but may also be carried by platelets. Platelets express more than 20 polymorphic antigenic determinants on their surface, which are called human platelet antigens (HPA), To determine the allele frequency of the HPA-1 to -5 in patients infected with HCV, blood samples were collected from 257 blood donors for the control group and from 191 patients infected with HCV. DNA was isolated and amplified for genes HPA-1 to -4 using PCR Sequence Specific Primers (PCR-SSP) and HPA-5 using PCR-Restriction Fragment Length Polymorphism (PCR-RFLP). The allelic and genotypic frequency of HPA-5a in patients infected with HCV was found to be significantly lower(P < 0.05) than in the controls, and HPA-5b from patients infected with HCV was significantly higher (P < 0.05) than in controls. The increase in HPA5b allelic frequency in HCV infection may indicate a possible association between HCV infection and HPAs. J. Med. Virol. 81:757-759, 2009. (C) 2009 Wiley-Liss, Inc.en
dc.format.extent757-759-
dc.language.isoeng-
dc.publisherWiley-liss-
dc.sourceWeb of Science-
dc.subjectallelic frequenciesen
dc.subjecthepatitis C virusen
dc.subjecthuman platelet antigensen
dc.subjectplateletsen
dc.titleAllelic Frequencies of HPA-1 to 5 Human Platelet Antigens in Patients Infected With Hepatitis C Virusen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationSão Paulo State Univ, UNESP, Botucatu Med Sch, Ctr Blood Transfus,Mol Biol Lab, Botucatu, SP, Brazil-
dc.description.affiliationSão Paulo State Univ, UNESP, Botucatu Med Sch, Dept Internal Med,Gastroenterol Div, Botucatu, SP, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Botucatu Med Sch, Ctr Blood Transfus,Mol Biol Lab, Botucatu, SP, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Botucatu Med Sch, Dept Internal Med,Gastroenterol Div, Botucatu, SP, Brazil-
dc.identifier.doi10.1002/jmv.21411-
dc.identifier.wosWOS:000263765900026-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Medical Virology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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