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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/116196
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dc.contributor.authorDe Vries, Teun J.-
dc.contributor.authorSchoenmaker, Ton-
dc.contributor.authorAerts, David-
dc.contributor.authorGrevers, Lilyanne C.-
dc.contributor.authorSouza, Pedro P. C.-
dc.contributor.authorNazmi, Kamran-
dc.contributor.authorVan De Wiel, Mark A.-
dc.contributor.authorYlstra, Bauke-
dc.contributor.authorVan Lent, Peter L.-
dc.contributor.authorLeenen, Pieter J. M.-
dc.contributor.authorEverts, Vincent-
dc.date.accessioned2015-03-18T15:52:34Z-
dc.date.accessioned2016-10-25T20:23:34Z-
dc.date.available2015-03-18T15:52:34Z-
dc.date.available2016-10-25T20:23:34Z-
dc.date.issued2015-01-01-
dc.identifierhttp://dx.doi.org/10.1002/jcp.24702-
dc.identifier.citationJournal Of Cellular Physiology. Hoboken: Wiley-blackwell, v. 230, n. 1, p. 210-225, 2015.-
dc.identifier.issn0021-9541-
dc.identifier.urihttp://hdl.handle.net/11449/116196-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/116196-
dc.description.abstractOsteoclasts and macrophages share progenitors that must receive decisive lineage signals driving them into their respective differentiation routes. Macrophage colony stimulation factor M-CSF is a common factor; bone is likely the stimulus for osteoclast differentiation. To elucidate the effect of both, shared mouse bone marrow precursor myeloid blast was pre-cultured with M-CSF on plastic and on bone. M-CSF priming prior to stimulation with M-CSF and osteoclast differentiation factor RANKL resulted in a complete loss of osteoclastogenic potential without bone. Such M-CSF primed cells expressed the receptor RANK, but lacked the crucial osteoclastogenic transcription factor NFATc1. This coincided with a steeply decreased expression of osteoclast genes TRACP and DC-STAMP, but an increased expression of the macrophage markers F4/80 and CD11b. Compellingly, M-CSF priming on bone accelerated the osteoclastogenic potential: M-CSF primed cells that had received only one day M-CSF and RANKL and were grown on bone already expressed an array of genes that are associated with osteoclast differentiation and these cells differentiated into osteoclasts within 2 days. Osteoclastogenesis-insensitive precursors grown in the absence of bone regained their osteoclastogenic potential when transferred to bone. This implies that adhesion to bone dictates the fate of osteoclast precursors. Common macrophage-osteoclast precursors may become insensitive to differentiate into osteoclasts and regain osteoclastogenesis when bound to bone or when in the vicinity of bone. J. Cell. Physiol. 229: 210-225, 2014. (c) 2014 Wiley Periodicals, Inc.en
dc.format.extent210-225-
dc.language.isoeng-
dc.publisherWiley-Blackwell-
dc.sourceWeb of Science-
dc.titleM-CSF Priming of Osteoclast Precursors Can Cause Osteoclastogenesis-Insensitivity, Which Can be Prevented and Overcome on Boneen
dc.typeoutro-
dc.contributor.institutionVrije Univ Amsterdam-
dc.contributor.institutionRadboud Univ Nijmegen-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniv Amsterdam-
dc.contributor.institutionUniv Med Ctr-
dc.description.affiliationVrije Univ Amsterdam, Univ Amsterdam, MOVE Res Inst, Dept Periodontol, NL-1081 LA Amsterdam, Netherlands-
dc.description.affiliationVrije Univ Amsterdam, Univ Amsterdam, MOVE Res Inst, Dept Oral Cell Biol, NL-1081 LA Amsterdam, Netherlands-
dc.description.affiliationRadboud Univ Nijmegen, Nijmegen Med Ctr, Dept Reumatol Res & Therapeut, NL-6525 ED Nijmegen, Netherlands-
dc.description.affiliationSao Paulo State Univ, Araraquara Sch Dent, Dept Physiol & Pathol, Araraquara, Brazil-
dc.description.affiliationUniv Amsterdam, Acad Ctr Dent Amsterdam ACTA, Dept Oral Biochem, NL-1081 LA Amsterdam, Netherlands-
dc.description.affiliationVrije Univ Amsterdam, MOVE Res Inst, NL-1081 LA Amsterdam, Netherlands-
dc.description.affiliationVrije Univ Amsterdam, Med Ctr, Dept Epidemiol & Biostat, NL-1081 LA Amsterdam, Netherlands-
dc.description.affiliationVrije Univ Amsterdam, Dept Math, NL-1081 LA Amsterdam, Netherlands-
dc.description.affiliationVrije Univ Amsterdam, Med Ctr, Dept Pathol, NL-1081 LA Amsterdam, Netherlands-
dc.description.affiliationVrije Univ Amsterdam, Med Ctr, Microarray Facil, NL-1081 LA Amsterdam, Netherlands-
dc.description.affiliationUniv Med Ctr, Erasmus MC, Dept Immunol, Rotterdam, Netherlands-
dc.description.affiliationUnespSao Paulo State Univ, Araraquara Sch Dent, Dept Physiol & Pathol, Araraquara, Brazil-
dc.identifier.doi10.1002/jcp.24702-
dc.identifier.wosWOS:000342762200020-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal Of Cellular Physiology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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