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DC Field | Value | Language |
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dc.contributor.author | Nogueira, M. N. M. | - |
dc.contributor.author | Aquino, S. G. | - |
dc.contributor.author | Rossa Júnior, Carlos | - |
dc.contributor.author | Spolidório, Denise Madalena Palomari | - |
dc.date.accessioned | 2015-03-18T15:52:55Z | - |
dc.date.accessioned | 2016-10-25T20:24:20Z | - |
dc.date.available | 2015-03-18T15:52:55Z | - |
dc.date.available | 2016-10-25T20:24:20Z | - |
dc.date.issued | 2014-09-01 | - |
dc.identifier | http://dx.doi.org/10.1007/s00011-014-0749-x | - |
dc.identifier.citation | Inflammation Research. Basel: Springer Basel Ag, v. 63, n. 9, p. 769-778, 2014. | - |
dc.identifier.issn | 1023-3830 | - |
dc.identifier.uri | http://hdl.handle.net/11449/116242 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/116242 | - |
dc.description.abstract | Tea tree oil (TTO) is an essential oil with anti-inflammatory properties, steam distilled from the plant Melaleuca alternifolia. We investigated the immunomodulatory properties of TTO and its components (terpinen-4-ol and alpha-terpineol) using lipopolysaccharide (LPS)-stimulated macrophages.The ability of TTO, terpinen-4-ol and alpha-terpineol to modulate the macrophage response to bacterial LPS stimulation was assessed by ELISA for tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-6 and IL-10 cytokine production and by western blotting for the activation of nuclear factor kappa B (NF-kappa B) and p38 mitogen-activated protein kinase (MAPK) signaling, which are associated with the expression of pro-inflammatory cytokines. We used a human monocytic cell line (U937) differentiated into macrophages.LPS induced the production of all cytokines, and TTO and its components significantly reduced the production of IL-1 beta, IL-6 and IL-10. The production of TNF-alpha was not affected by either TTO or its major components. The modulation of cytokine production was not mediated by changes in NF-kappa B or p38 MAPK activation.TTO, terpinen-4-ol and alpha-terpineol can suppress the production of inflammatory mediators in LPS-stimulated human macrophages; this inhibition was mediated by interfering with the NF-kB, p38 or ERK MAPK pathways. | en |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.format.extent | 769-778 | - |
dc.language.iso | eng | - |
dc.publisher | Springer | - |
dc.source | Web of Science | - |
dc.subject | Tea tree oil | en |
dc.subject | Macrophages | en |
dc.subject | Cytokines | en |
dc.subject | Inflammation | en |
dc.title | Terpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1 beta, IL-6 and IL-10 on human macrophages | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | UNESP, Dept Diag & Surg, Sch Dent Araraquara, Araraquara, SP, Brazil | - |
dc.description.affiliation | UNESP, Dept Physiol & Pathol, Sch Dent Araraquara, Araraquara, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP, Dept Diag & Surg, Sch Dent Araraquara, Araraquara, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP, Dept Physiol & Pathol, Sch Dent Araraquara, Araraquara, SP, Brazil | - |
dc.description.sponsorshipId | FAPESP: 09/54190-0 | - |
dc.description.sponsorshipId | FAPESP: 10/18968-3 | - |
dc.identifier.doi | 10.1007/s00011-014-0749-x | - |
dc.identifier.wos | WOS:000340557100007 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Inflammation Research | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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