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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/116242
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dc.contributor.authorNogueira, M. N. M.-
dc.contributor.authorAquino, S. G.-
dc.contributor.authorRossa Júnior, Carlos-
dc.contributor.authorSpolidório, Denise Madalena Palomari-
dc.date.accessioned2015-03-18T15:52:55Z-
dc.date.accessioned2016-10-25T20:24:20Z-
dc.date.available2015-03-18T15:52:55Z-
dc.date.available2016-10-25T20:24:20Z-
dc.date.issued2014-09-01-
dc.identifierhttp://dx.doi.org/10.1007/s00011-014-0749-x-
dc.identifier.citationInflammation Research. Basel: Springer Basel Ag, v. 63, n. 9, p. 769-778, 2014.-
dc.identifier.issn1023-3830-
dc.identifier.urihttp://hdl.handle.net/11449/116242-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/116242-
dc.description.abstractTea tree oil (TTO) is an essential oil with anti-inflammatory properties, steam distilled from the plant Melaleuca alternifolia. We investigated the immunomodulatory properties of TTO and its components (terpinen-4-ol and alpha-terpineol) using lipopolysaccharide (LPS)-stimulated macrophages.The ability of TTO, terpinen-4-ol and alpha-terpineol to modulate the macrophage response to bacterial LPS stimulation was assessed by ELISA for tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-6 and IL-10 cytokine production and by western blotting for the activation of nuclear factor kappa B (NF-kappa B) and p38 mitogen-activated protein kinase (MAPK) signaling, which are associated with the expression of pro-inflammatory cytokines. We used a human monocytic cell line (U937) differentiated into macrophages.LPS induced the production of all cytokines, and TTO and its components significantly reduced the production of IL-1 beta, IL-6 and IL-10. The production of TNF-alpha was not affected by either TTO or its major components. The modulation of cytokine production was not mediated by changes in NF-kappa B or p38 MAPK activation.TTO, terpinen-4-ol and alpha-terpineol can suppress the production of inflammatory mediators in LPS-stimulated human macrophages; this inhibition was mediated by interfering with the NF-kB, p38 or ERK MAPK pathways.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent769-778-
dc.language.isoeng-
dc.publisherSpringer-
dc.sourceWeb of Science-
dc.subjectTea tree oilen
dc.subjectMacrophagesen
dc.subjectCytokinesen
dc.subjectInflammationen
dc.titleTerpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1 beta, IL-6 and IL-10 on human macrophagesen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUNESP, Dept Diag & Surg, Sch Dent Araraquara, Araraquara, SP, Brazil-
dc.description.affiliationUNESP, Dept Physiol & Pathol, Sch Dent Araraquara, Araraquara, SP, Brazil-
dc.description.affiliationUnespUNESP, Dept Diag & Surg, Sch Dent Araraquara, Araraquara, SP, Brazil-
dc.description.affiliationUnespUNESP, Dept Physiol & Pathol, Sch Dent Araraquara, Araraquara, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 09/54190-0-
dc.description.sponsorshipIdFAPESP: 10/18968-3-
dc.identifier.doi10.1007/s00011-014-0749-x-
dc.identifier.wosWOS:000340557100007-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofInflammation Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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