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http://acervodigital.unesp.br/handle/11449/116263
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DC Field | Value | Language |
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dc.contributor.author | Oliveira Alves, Monica Ghislaine | - |
dc.contributor.author | Delgado, Adriana da Mota | - |
dc.contributor.author | Balducci, Ivan | - |
dc.contributor.author | Carvalho, Yasmin Rodarte | - |
dc.contributor.author | Rodrigues Cavalcante, Ana Sueli | - |
dc.contributor.author | Almeida, Janete Dias | - |
dc.date.accessioned | 2015-03-18T15:52:59Z | - |
dc.date.accessioned | 2016-10-25T20:24:23Z | - |
dc.date.available | 2015-03-18T15:52:59Z | - |
dc.date.available | 2016-10-25T20:24:23Z | - |
dc.date.issued | 2014-11-01 | - |
dc.identifier | http://dx.doi.org/10.1007/s00403-014-1500-8 | - |
dc.identifier.citation | Archives Of Dermatological Research. New York: Springer, v. 306, n. 9, p. 837-841, 2014. | - |
dc.identifier.issn | 0340-3696 | - |
dc.identifier.uri | http://hdl.handle.net/11449/116263 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/116263 | - |
dc.description.abstract | Actinic cheilitis exhibits a potential of malignant transformation in 10-20 % of cases. The objective of this study was to compare the expression of MDM2 and SUMO-1 proteins between actinic cheilitis (AC) and squamous cell carcinoma (SCC) of the lip. The sample consisted of lower lip mucosa specimens obtained from cases with a clinical and histopathological diagnosis of AC (n = 26) and SCC (n = 25) and specimens of labial semi-mucosa (n = 15) without clinical alterations or inflammation. The tissue samples were stained with hematoxylin-eosin and anti-MDM2 and anti-SUMO-1 antibodies. Data were analyzed by the Kruskal-Wallis and Dunn's tests (5 %). The median expression of MDM2 (kW = 36.8565; df = 3-1 = 2; p = 0.0001) and SUMO-1 (kW = 32.7080; df = 3-1 = 2; p = 0.0001) was similar in cases of AC and SCC of the lip, but differed significantly from that observed for normal labial semi-mucosa. Despite the limitations of the present study, immunohistochemistry demonstrated the overexpression of important proteins (MDM2 and SUMO-1) related to regulatory mechanisms of apoptosis in AC and SCC of the lip, but further studies are needed. | en |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.format.extent | 837-841 | - |
dc.language.iso | eng | - |
dc.publisher | Springer | - |
dc.source | Web of Science | - |
dc.subject | Actinic cheilitis | en |
dc.subject | Squamous cell carcinoma | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Proto-Oncogene Proteins c-mdm2 | en |
dc.subject | SUMO-1 protein | en |
dc.title | Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Univ Estadual Paulista, UNESP, Inst Sci & Technol, Dept Biosci & Oral Diag, BR-12245000 Sao Jose Dos Campos, SP, Brazil | - |
dc.description.affiliation | Univ Estadual Paulista, Inst Sci & Technol, Dept Social Sci & Pediat Dent, UNESP, BR-12245000 Sao Jose Dos Campos, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, UNESP, Inst Sci & Technol, Dept Biosci & Oral Diag, BR-12245000 Sao Jose Dos Campos, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, Inst Sci & Technol, Dept Social Sci & Pediat Dent, UNESP, BR-12245000 Sao Jose Dos Campos, SP, Brazil | - |
dc.identifier.doi | 10.1007/s00403-014-1500-8 | - |
dc.identifier.wos | WOS:000344168300007 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Archives Of Dermatological Research | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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