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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/116360
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dc.contributor.authorPereira da Silva, Victor Hugo-
dc.contributor.authorGomes de Moura, Carolina Foot-
dc.contributor.authorPidone Ribeiro, Flavia Andressa-
dc.contributor.authorCesar, Augusto-
dc.contributor.authorSeabra Pereira, Camilo Dias-
dc.contributor.authorDias Silva, Marcelo Jose-
dc.contributor.authorVilegas, Wagner-
dc.contributor.authorRibeiro, Daniel Araki-
dc.date.accessioned2015-03-18T15:53:08Z-
dc.date.accessioned2016-10-25T20:24:36Z-
dc.date.available2015-03-18T15:53:08Z-
dc.date.available2016-10-25T20:24:36Z-
dc.date.issued2014-11-01-
dc.identifierhttp://dx.doi.org/10.1007/s11356-014-3261-5-
dc.identifier.citationEnvironmental Science And Pollution Research. Heidelberg: Springer Heidelberg, v. 21, n. 22, p. 13069-13080, 2014.-
dc.identifier.issn0944-1344-
dc.identifier.urihttp://hdl.handle.net/11449/116360-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/116360-
dc.description.abstractThe aim of this study was to evaluate cytotoxicity and genotoxicity in multiple organs of rats induced by municipal effluent released by submarine outfall in city of Santos. A total of 20 male Wistar rats were exposed to effluents by drinking water ad libitum at concentrations of 0, 10, 50, and 100% for 30 days. Microscopic analysis revealed severe lesions such as necrosis and hemorrhagic areas in liver and kidney from animals exposed to effluent at 50 and 100% concentration. DNA damage in peripheral blood, liver, and kidney cells were detected by comet assay at higher concentrations of effluent. Moreover, a decrease DNA repair capacity was detected in liver cells. Significant statistical differences (p<0.05) for micronucleated cells from liver were noticed at 50% concentration of effluent. Taken together, our results demonstrate that municipal effluent is able to induce cytotoxicity and genotoxicity in multiple organs of Wistar rats.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.format.extent13069-13080-
dc.language.isoeng-
dc.publisherSpringer-
dc.sourceWeb of Science-
dc.subjectMunicipal effluenten
dc.subjectApoptosisen
dc.subjectMutagenicityen
dc.subjectDNA damageen
dc.subjectRaten
dc.titleGenotoxicity and cytotoxicity induced by municipal effluent in multiple organs of Wistar ratsen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Dept Biosci, BR-11060001 Santos, SP, Brazil-
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Dept Pathol, Sao Paulo, SP, Brazil-
dc.description.affiliationUniv Fed Sao Paulo, Dept Marine Sci, UNIFESP, Sao Paulo, SP, Brazil-
dc.description.affiliationSao Paulo State Univ, UNESP, Sao Vicente, SP, Brazil-
dc.description.affiliationUnespSao Paulo State Univ, UNESP, Sao Vicente, SP, Brazil-
dc.identifier.doi10.1007/s11356-014-3261-5-
dc.identifier.wosWOS:000344546900043-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofEnvironmental Science And Pollution Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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