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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/116393
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dc.contributor.authorCarreira, Ana Claudia-
dc.contributor.authorAlves, Gutemberg Gomes-
dc.contributor.authorZambuzzi, William Fernando-
dc.contributor.authorSogayar, Mari Cleide-
dc.contributor.authorGranjeiro, Jose Mauro-
dc.date.accessioned2015-03-18T15:53:15Z-
dc.date.accessioned2016-10-25T20:24:41Z-
dc.date.available2015-03-18T15:53:15Z-
dc.date.available2016-10-25T20:24:41Z-
dc.date.issued2014-11-01-
dc.identifierhttp://dx.doi.org/10.1016/j.abb.2014.07.011-
dc.identifier.citationArchives Of Biochemistry And Biophysics. New York: Elsevier Science Inc, v. 561, p. 64-73, 2014.-
dc.identifier.issn0003-9861-
dc.identifier.urihttp://hdl.handle.net/11449/116393-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/116393-
dc.description.abstractBone Morphogenetic Proteins (BMPs) are multifunctional secreted cytokines, which belong to the TGF-beta superfamily. These glycoproteins act as a disulfide-linked homo- or heterodimers, being potent regulators of bone and cartilage formation and repair, cell proliferation during embryonic development and bone homeostasis in the adult. BMPs are promising molecules for tissue engineering and bone therapy. The present review discusses this family of proteins, their structure and biological function, their therapeutic applications and drawbacks, their effects on mesenchymal stem cells differentiation, and the cell signaling pathways involved in this process. (C) 2014 Published by Elsevier Inc.en
dc.description.sponsorshipBrazilian Federal agency-
dc.description.sponsorshipSao Paulo State research agency-
dc.format.extent64-73-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectBone Morphogenetic Proteinsen
dc.subjectOsteogenesis inducing proteinsen
dc.subjectPeptide growth factorsen
dc.subjectBone repairen
dc.subjectExtracellular matrixen
dc.subjectTissue engineeringen
dc.titleBone Morphogenetic Proteins: Structure, biological function and therapeutic applicationsen
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Federal Fluminense (UFF)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionNatl Inst Metrol Qual & Technol-
dc.description.affiliationUniv Sao Paulo, Dept Biochem, Inst Chem, BR-05508000 Sao Paulo, Brazil-
dc.description.affiliationUniv Sao Paulo, Sch Med, Dept Clin Med, NUCEL NETCEM Cell & Mol Therapy Ctr, BR-05508000 Sao Paulo, Brazil-
dc.description.affiliationUniv Fed Fluminense, Inst Biol, Dept Cell & Mol Biol, Niteroi, RJ, Brazil-
dc.description.affiliationUniv Estadual Paulista, UNESP, Biosci Inst, Dept Chem & Biochem, Botucatu, SP, Brazil-
dc.description.affiliationNatl Inst Metrol Qual & Technol, Bioengn Div, Duque De Caxias, RJ, Brazil-
dc.description.affiliationUniv Fed Fluminense, Sch Dent, Dept Dent Mat, Niteroi, RJ, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Biosci Inst, Dept Chem & Biochem, Botucatu, SP, Brazil-
dc.identifier.doi10.1016/j.abb.2014.07.011-
dc.identifier.wosWOS:000342863300009-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofArchives Of Biochemistry And Biophysics-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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