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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/116837
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dc.contributor.authorRocha, Claudia Quintino da-
dc.contributor.authorQueiroz, Emerson Ferreira-
dc.contributor.authorMeira, Cassio Santana-
dc.contributor.authorMagalhaes Moreira, Diogo Rodrigo-
dc.contributor.authorPereira Soares, Milena Botelho-
dc.contributor.authorMarcourt, Laurence-
dc.contributor.authorVilegas, Wagner-
dc.contributor.authorWolfender, Jean-Luc-
dc.date.accessioned2015-03-18T15:54:15Z-
dc.date.accessioned2016-10-25T20:28:10Z-
dc.date.available2015-03-18T15:54:15Z-
dc.date.available2016-10-25T20:28:10Z-
dc.date.issued2014-06-01-
dc.identifierhttp://dx.doi.org/10.1021/np401060j-
dc.identifier.citationJournal Of Natural Products. Washington: Amer Chemical Soc, v. 77, n. 6, p. 1345-1350, 2014.-
dc.identifier.issn0163-3864-
dc.identifier.urihttp://hdl.handle.net/11449/116837-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/116837-
dc.description.abstractThe nonpolar fraction of an aqueous ethanol extract of the roots of Arrabidaea brachypoda, a Brazilian medicinal plant, demonstrated significant in vitro activity against Trypanosoma cruzi, the parasite responsible for Chagas disease. Targeted isolation of the active constituents led to the isolation of three new dimeric flavonoids (1-3), and their structures were elucidated using UV, NMR, and HRMS analysis, as well as by chemical derivatization. The anti-T. cruzi activity and cytotoxicity toward mammalian cells were determined for these substances. Compound 1 exhibited no activity toward T. cruzi, while flavonoids 2 and 3 exhibited selective activity against these trypomastigotes. Compounds 2 and 3 inhibited the parasite invasion process and its intracellular development in host cells with similar potencies to benznidazole. In addition, compound 2 reduced the blood parasitemia of T. cruzi-infected mice. This study has revealed that these two dimeric flavonoids represent potential anti-T. cruzi lead compounds for further drug development.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent1345-1350-
dc.language.isoeng-
dc.publisherAmer Chemical Soc-
dc.sourceWeb of Science-
dc.titleDimeric Flavonoids from Arrabidaea brachypoda and Assessment of Their Anti-Trypanosoma cruzi Activityen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniv Lausanne-
dc.contributor.institutionFundacao Oswaldo Cruz Fiocruz-
dc.description.affiliationUniv Estadual Paulista, UNESP, Lab Biodiversidade & Sustentabilidade, BR-11330900 Sao Vicente, Brazil-
dc.description.affiliationUniv Lausanne, Univ Geneva, Sch Pharmaceut Sci Phytochem & Bioact Nat Prod, CH-1211 Geneva 4, Switzerland-
dc.description.affiliationFundacao Oswaldo Cruz Fiocruz, Ctr Pesquisas Goncalo Moniz, BR-40296710 Salvador, BA, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Lab Biodiversidade & Sustentabilidade, BR-11330900 Sao Vicente, Brazil-
dc.description.sponsorshipIdFAPESP: 09/52237-9-
dc.description.sponsorshipIdFAPESP: 09/17877-7-
dc.identifier.doi10.1021/np401060j-
dc.identifier.wosWOS:000340222700014-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal Of Natural Products-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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