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http://acervodigital.unesp.br/handle/11449/116837
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DC Field | Value | Language |
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dc.contributor.author | Rocha, Claudia Quintino da | - |
dc.contributor.author | Queiroz, Emerson Ferreira | - |
dc.contributor.author | Meira, Cassio Santana | - |
dc.contributor.author | Magalhaes Moreira, Diogo Rodrigo | - |
dc.contributor.author | Pereira Soares, Milena Botelho | - |
dc.contributor.author | Marcourt, Laurence | - |
dc.contributor.author | Vilegas, Wagner | - |
dc.contributor.author | Wolfender, Jean-Luc | - |
dc.date.accessioned | 2015-03-18T15:54:15Z | - |
dc.date.accessioned | 2016-10-25T20:28:10Z | - |
dc.date.available | 2015-03-18T15:54:15Z | - |
dc.date.available | 2016-10-25T20:28:10Z | - |
dc.date.issued | 2014-06-01 | - |
dc.identifier | http://dx.doi.org/10.1021/np401060j | - |
dc.identifier.citation | Journal Of Natural Products. Washington: Amer Chemical Soc, v. 77, n. 6, p. 1345-1350, 2014. | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | http://hdl.handle.net/11449/116837 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/116837 | - |
dc.description.abstract | The nonpolar fraction of an aqueous ethanol extract of the roots of Arrabidaea brachypoda, a Brazilian medicinal plant, demonstrated significant in vitro activity against Trypanosoma cruzi, the parasite responsible for Chagas disease. Targeted isolation of the active constituents led to the isolation of three new dimeric flavonoids (1-3), and their structures were elucidated using UV, NMR, and HRMS analysis, as well as by chemical derivatization. The anti-T. cruzi activity and cytotoxicity toward mammalian cells were determined for these substances. Compound 1 exhibited no activity toward T. cruzi, while flavonoids 2 and 3 exhibited selective activity against these trypomastigotes. Compounds 2 and 3 inhibited the parasite invasion process and its intracellular development in host cells with similar potencies to benznidazole. In addition, compound 2 reduced the blood parasitemia of T. cruzi-infected mice. This study has revealed that these two dimeric flavonoids represent potential anti-T. cruzi lead compounds for further drug development. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.format.extent | 1345-1350 | - |
dc.language.iso | eng | - |
dc.publisher | Amer Chemical Soc | - |
dc.source | Web of Science | - |
dc.title | Dimeric Flavonoids from Arrabidaea brachypoda and Assessment of Their Anti-Trypanosoma cruzi Activity | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Univ Lausanne | - |
dc.contributor.institution | Fundacao Oswaldo Cruz Fiocruz | - |
dc.description.affiliation | Univ Estadual Paulista, UNESP, Lab Biodiversidade & Sustentabilidade, BR-11330900 Sao Vicente, Brazil | - |
dc.description.affiliation | Univ Lausanne, Univ Geneva, Sch Pharmaceut Sci Phytochem & Bioact Nat Prod, CH-1211 Geneva 4, Switzerland | - |
dc.description.affiliation | Fundacao Oswaldo Cruz Fiocruz, Ctr Pesquisas Goncalo Moniz, BR-40296710 Salvador, BA, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, UNESP, Lab Biodiversidade & Sustentabilidade, BR-11330900 Sao Vicente, Brazil | - |
dc.description.sponsorshipId | FAPESP: 09/52237-9 | - |
dc.description.sponsorshipId | FAPESP: 09/17877-7 | - |
dc.identifier.doi | 10.1021/np401060j | - |
dc.identifier.wos | WOS:000340222700014 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Journal Of Natural Products | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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