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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/117160
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dc.contributor.authorMelo, Guilherme Dias de-
dc.contributor.authorSilva, José Eduardo dos Santos-
dc.contributor.authorGrano, Fernanda Grecco-
dc.contributor.authorHomem, Camila Guariz-
dc.contributor.authorMachado, Gisele Fabrino-
dc.date.accessioned2015-03-18T15:55:20Z-
dc.date.accessioned2016-10-25T20:33:03Z-
dc.date.available2015-03-18T15:55:20Z-
dc.date.available2016-10-25T20:33:03Z-
dc.date.issued2014-12-01-
dc.identifierhttp://dx.doi.org/10.1111/pim.12148-
dc.identifier.citationParasite Immunology. Hoboken: Wiley-blackwell, v. 36, n. 12, p. 726-731, 2014.-
dc.identifier.issn0141-9838-
dc.identifier.urihttp://hdl.handle.net/11449/117160-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/117160-
dc.description.abstractVisceral leishmaniasis is an important parasitic disease that affects humans and animals. The response against the protozoan involves the interaction of both innate and adaptive branches of the immune system, and an important immune sensor is represented by the toll-like receptor (TLR) family. Here, we investigated the pattern of TLR-2, TLR-4 and TLR-9 gene expression in different compartments (brain, choroid plexus, spleen and lymph node) of dogs naturally infected with Leishmania infantum. Gene expression of the TLRs varied according to the compartment evaluated. In the brain, there was only an upregulation of TLR-2, whereas in the choroid plexus, TLR-2 and TLR-9 were both upregulated. Further, the peripheral lymphoid organs (spleen and lymph nodes) showed increased TLR-2 and TLR-4 expression. This study provides the first insight about TLR expression in the central nervous system of infected dogs, and gives additional evidence of the compartmentalization of the immune response during visceral leishmaniasis.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent726-731-
dc.language.isoeng-
dc.publisherWiley-Blackwell-
dc.sourceWeb of Science-
dc.subjectcentral nervous systemen
dc.subjectinflammationen
dc.subjectinnate immunityen
dc.subjectLeishmania infantumen
dc.subjectpattern recognition receptorsen
dc.titleCompartmentalized gene expression of toll-like receptors 2, 4 and 9 in the brain and peripheral lymphoid organs during canine visceral leishmaniasisen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUNESP Univ Estadual Paulista, Coll Vet Med, Lab Appl Pathol LApap, Sao Paulo, Brazil-
dc.description.affiliationUNESP Univ Estadual Paulista, Coll Vet Med, Sao Paulo, Brazil-
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Coll Vet Med, Lab Appl Pathol LApap, Sao Paulo, Brazil-
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Coll Vet Med, Sao Paulo, Brazil-
dc.description.sponsorshipIdFAPESP: 11/24172-0-
dc.description.sponsorshipIdFAPESP: 12/10415-0-
dc.identifier.doi10.1111/pim.12148-
dc.identifier.wosWOS:000345631600012-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofParasite Immunology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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