Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/117191
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Santos, Cristiane dos | - |
dc.contributor.author | Ferreira, Francielle Batista D. | - |
dc.contributor.author | Goncalves-Neto, Luiz M. | - |
dc.contributor.author | Taboga, Sebastiao Roberto | - |
dc.contributor.author | Boschero, Antonio Carlos | - |
dc.contributor.author | Rafacho, Alex | - |
dc.date.accessioned | 2015-03-18T15:55:24Z | - |
dc.date.accessioned | 2016-10-25T20:34:28Z | - |
dc.date.available | 2015-03-18T15:55:24Z | - |
dc.date.available | 2016-10-25T20:34:28Z | - |
dc.date.issued | 2014-10-01 | - |
dc.identifier | http://dx.doi.org/10.1139/cjpp-2014-0259 | - |
dc.identifier.citation | Canadian Journal Of Physiology And Pharmacology. Ottawa: Canadian Science Publishing, Nrc Research Press, v. 92, n. 10, p. 867-878, 2014. | - |
dc.identifier.issn | 0008-4212 | - |
dc.identifier.uri | http://hdl.handle.net/11449/117191 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/117191 | - |
dc.description.abstract | The disruption to glucose homeostasis upon glucocorticoid (GC) treatment in adult male rats has not been fully characterized in older rats or in females. Thus, we evaluated the age-and gender-related changes in glucose homeostasis in GC-treated rats. We injected male and female rats at 3 months and 12 months of age with either dexamethasone (1.0 mg/kg body mass, intraperitoneally) or saline, daily for 5 days. All of the GC-treated rats had decreased body mass and food intake, and adrenal hypotrophy. Increased glycemia was observed in all of the GC-treated groups and only the 3-month-old female rats were not glucose intolerant. Dexamethasone treatment resulted in hyperinsulinemia and hypertriacylglyceridemia in all of the GC-treated rats. The glucose-stimulated insulin secretion (GSIS) was higher in all of the dexamethasone-treated animals, but it was less pronounced in the older animals. The beta-cell mass was increased in the younger male rats treated with dexamethasone. We conclude that dexamethasone treatment induces glucose intolerance in both the 3- and 12-month-old male rats as well as hyperinsulinemia and augmented GSIS. Three-month-old female rats are protected from glucose intolerance caused by GC, whereas 12-month-old female rats developed the same complications that were present in 3- and 12-month-old male rats. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.description.sponsorship | Instituto Nacional de Ciencia e Tecnologia: Obesidade e Diabetes | - |
dc.format.extent | 867-878 | - |
dc.language.iso | eng | - |
dc.publisher | Canadian Science Publishing, Nrc Research Press | - |
dc.source | Web of Science | - |
dc.subject | dexamethasone | en |
dc.subject | female | en |
dc.subject | glucose tolerance | en |
dc.subject | insulin secretion | en |
dc.subject | insulin sensitivity | en |
dc.title | Age- and gender-related changes in glucose homeostasis in glucocorticoid-treated rats | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Federal de Santa Catarina (UFSC) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Universidade Estadual de Campinas (UNICAMP) | - |
dc.description.affiliation | Fed Univ Santa Catarina UFSC, Dept Physiol Sci, Ctr Biol Sci, BR-88040900 Florianopolis, SC, Brazil | - |
dc.description.affiliation | Sao Paulo State Univ UNESP, Dept Biol, Inst Biosci Humanities & Exact Sci, Sao Jose Do Rio Preto, Brazil | - |
dc.description.affiliation | State Univ Campinas UNICAMP, Dept Struct & Funct Biol, Inst Biol, Campinas, SP, Brazil | - |
dc.description.affiliation | State Univ Campinas UNICAMP, OCRC, Campinas, SP, Brazil | - |
dc.description.affiliationUnesp | Sao Paulo State Univ UNESP, Dept Biol, Inst Biosci Humanities & Exact Sci, Sao Jose Do Rio Preto, Brazil | - |
dc.description.sponsorshipId | CNPq: 471397/2011-3 | - |
dc.identifier.doi | 10.1139/cjpp-2014-0259 | - |
dc.identifier.wos | WOS:000343099500009 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.relation.ispartof | Canadian Journal Of Physiology And Pharmacology | - |
dc.identifier.orcid | 0000-0002-0970-4288 | pt |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.