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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/117191
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dc.contributor.authorSantos, Cristiane dos-
dc.contributor.authorFerreira, Francielle Batista D.-
dc.contributor.authorGoncalves-Neto, Luiz M.-
dc.contributor.authorTaboga, Sebastiao Roberto-
dc.contributor.authorBoschero, Antonio Carlos-
dc.contributor.authorRafacho, Alex-
dc.date.accessioned2015-03-18T15:55:24Z-
dc.date.accessioned2016-10-25T20:34:28Z-
dc.date.available2015-03-18T15:55:24Z-
dc.date.available2016-10-25T20:34:28Z-
dc.date.issued2014-10-01-
dc.identifierhttp://dx.doi.org/10.1139/cjpp-2014-0259-
dc.identifier.citationCanadian Journal Of Physiology And Pharmacology. Ottawa: Canadian Science Publishing, Nrc Research Press, v. 92, n. 10, p. 867-878, 2014.-
dc.identifier.issn0008-4212-
dc.identifier.urihttp://hdl.handle.net/11449/117191-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/117191-
dc.description.abstractThe disruption to glucose homeostasis upon glucocorticoid (GC) treatment in adult male rats has not been fully characterized in older rats or in females. Thus, we evaluated the age-and gender-related changes in glucose homeostasis in GC-treated rats. We injected male and female rats at 3 months and 12 months of age with either dexamethasone (1.0 mg/kg body mass, intraperitoneally) or saline, daily for 5 days. All of the GC-treated rats had decreased body mass and food intake, and adrenal hypotrophy. Increased glycemia was observed in all of the GC-treated groups and only the 3-month-old female rats were not glucose intolerant. Dexamethasone treatment resulted in hyperinsulinemia and hypertriacylglyceridemia in all of the GC-treated rats. The glucose-stimulated insulin secretion (GSIS) was higher in all of the dexamethasone-treated animals, but it was less pronounced in the older animals. The beta-cell mass was increased in the younger male rats treated with dexamethasone. We conclude that dexamethasone treatment induces glucose intolerance in both the 3- and 12-month-old male rats as well as hyperinsulinemia and augmented GSIS. Three-month-old female rats are protected from glucose intolerance caused by GC, whereas 12-month-old female rats developed the same complications that were present in 3- and 12-month-old male rats.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipInstituto Nacional de Ciencia e Tecnologia: Obesidade e Diabetes-
dc.format.extent867-878-
dc.language.isoeng-
dc.publisherCanadian Science Publishing, Nrc Research Press-
dc.sourceWeb of Science-
dc.subjectdexamethasoneen
dc.subjectfemaleen
dc.subjectglucose toleranceen
dc.subjectinsulin secretionen
dc.subjectinsulin sensitivityen
dc.titleAge- and gender-related changes in glucose homeostasis in glucocorticoid-treated ratsen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.description.affiliationFed Univ Santa Catarina UFSC, Dept Physiol Sci, Ctr Biol Sci, BR-88040900 Florianopolis, SC, Brazil-
dc.description.affiliationSao Paulo State Univ UNESP, Dept Biol, Inst Biosci Humanities & Exact Sci, Sao Jose Do Rio Preto, Brazil-
dc.description.affiliationState Univ Campinas UNICAMP, Dept Struct & Funct Biol, Inst Biol, Campinas, SP, Brazil-
dc.description.affiliationState Univ Campinas UNICAMP, OCRC, Campinas, SP, Brazil-
dc.description.affiliationUnespSao Paulo State Univ UNESP, Dept Biol, Inst Biosci Humanities & Exact Sci, Sao Jose Do Rio Preto, Brazil-
dc.description.sponsorshipIdCNPq: 471397/2011-3-
dc.identifier.doi10.1139/cjpp-2014-0259-
dc.identifier.wosWOS:000343099500009-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofCanadian Journal Of Physiology And Pharmacology-
dc.identifier.orcid0000-0002-0970-4288pt
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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