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http://acervodigital.unesp.br/handle/11449/117256
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DC Field | Value | Language |
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dc.contributor.author | Ruiz Lima, Aline Regina | - |
dc.contributor.author | Martinez, Paula Felippe | - |
dc.contributor.author | Damatto, Ricardo Luiz | - |
dc.contributor.author | Mariano Cezar, Marcelo Diarcadia | - |
dc.contributor.author | Guizoni, Daniele Mendes | - |
dc.contributor.author | Bonomo, Camila | - |
dc.contributor.author | Oliveira, Silvio Assis | - |
dc.contributor.author | Silva, Maeli Dal-Pai | - |
dc.contributor.author | Zornoff, Leonardo Antonio Mamede | - |
dc.contributor.author | Okoshi, Katashi | - |
dc.contributor.author | Okoshi, Marina Politi | - |
dc.date.accessioned | 2015-03-18T15:55:39Z | - |
dc.date.accessioned | 2016-10-25T20:34:54Z | - |
dc.date.available | 2015-03-18T15:55:39Z | - |
dc.date.available | 2016-10-25T20:34:54Z | - |
dc.date.issued | 2014-01-01 | - |
dc.identifier | http://dx.doi.org/10.1159/000363003 | - |
dc.identifier.citation | Cellular Physiology And Biochemistry. Basel: Karger, v. 34, n. 2, p. 333-345, 2014. | - |
dc.identifier.issn | 1015-8987 | - |
dc.identifier.uri | http://hdl.handle.net/11449/117256 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/117256 | - |
dc.description.abstract | Background: Intracellular signaling pathways involved in skeletal myosin heavy chain (MyHC) isofornn alterations during heart failure (HF) are not completely understood. We tested the hypothesis that diaphragm expression of mitogen-activated protein kinases (MAPK) and myogenic regulatory factors is changed in rats with myocardial infarction (MI) induced HF. Methods: Six months after MI rats were subjected to transthoracic echocardiography. After euthanasia, infarcted rats were subdivided in MI/HF- group (with no HF evidence; n=10), and MI/HF+ (with right ventricular hypertrophy and lung congestion; n=10). Sham operated rats were used as controls (n=10). MyHC isofornns were analyzed by electrophoresis. Statistical analysis: ANOVA and Pearson correlation. Results: MI/HF- had left cardiac chambers dilation with systolic and diastolic left ventricular dysfunction. Cardiac injury was more intense in MI/HF+ than MI/HF-. MyHC I isoform percentage was higher in MI/HF+ than MI/HF-, and IIb isoform lower in MI/HF+ than Sham. Left atrial diameter-to-body weight ratio positively correlated with MyHC I (p=0.005) and negatively correlated with MyHC IIb (p=0.02). TNF-alpha serum concentration positively correlated with MyHC I isoform. Total and phosphorylated ERK was lower in MI/HF- and MI/HF+ than Sham. Phosphorylated JNK was lower in MI/HF- than Sham. JNK and p38 did not differ between groups. Expression of NF-kappa B and the myogenic regulatory factors MyoD, myogenin, and MRF4 was similar between groups. Conclusion: Diaphragm MyHC fast-to-slow shift is related to cardiac dysfunction severity and TNF-alpha serum levels in infarcted rats. Reduced ERK expression seems to participate in MyHC isofornn changes. Myogenic regulatory factors and NF-kappa B do not modulate diaphragm MyHC distribution during chronic HF. Copyright (C) 2014 S. Karger AG, Basel | en |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.format.extent | 333-345 | - |
dc.language.iso | eng | - |
dc.publisher | Karger | - |
dc.source | Web of Science | - |
dc.subject | Skeletal muscle | en |
dc.subject | MAPK | en |
dc.subject | Myogenic regulatory factors | en |
dc.subject | Myosin heavy chain isoforms | en |
dc.subject | Echocardiography | en |
dc.subject | Myocardial infarction | en |
dc.title | Heart Failure-Induced Diaphragm Myopathy | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Universidade Federal de Mato Grosso do Sul (UFMS) | - |
dc.description.affiliation | UNESP, Botucatu Med Sch, Dept Internal Med, Botocutu, SP, Brazil | - |
dc.description.affiliation | Fed Univ Mato Grosso Do Sul UFMS, Biol Sci & Hlth Ctr, Campo Grande, MS, Brazil | - |
dc.description.affiliation | UNESP, Biosci Inst, Dept Morphol, Botucatu, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP, Botucatu Med Sch, Dept Internal Med, Botocutu, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP, Biosci Inst, Dept Morphol, Botucatu, SP, Brazil | - |
dc.description.sponsorshipId | CNPq: 306857/2012-0 | - |
dc.description.sponsorshipId | CNPq: 306845/2012-1 | - |
dc.description.sponsorshipId | FAPESP: 07/57499-6 | - |
dc.description.sponsorshipId | FAPESP: 10/50084-8 | - |
dc.description.sponsorshipId | FAPESP: 08/58655-4 | - |
dc.identifier.doi | 10.1159/000363003 | - |
dc.identifier.wos | WOS:000343764600010 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.identifier.file | WOS000343764600010.pdf | - |
dc.relation.ispartof | Cellular Physiology And Biochemistry | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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