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dc.contributor.authorSilva, Patricia Bento da-
dc.contributor.authorSantos Ramos, Matheus Aparecido dos-
dc.contributor.authorBonifacio, Bruna Vidal-
dc.contributor.authorSilveira Negri, Kamila Maria-
dc.contributor.authorSato, Mariana Rillo-
dc.contributor.authorBauab, Taís Maria-
dc.contributor.authorChorilli, Marlus-
dc.date.accessioned2015-03-18T15:55:43Z-
dc.date.accessioned2016-10-25T20:34:59Z-
dc.date.available2015-03-18T15:55:43Z-
dc.date.available2016-10-25T20:34:59Z-
dc.date.issued2014-09-01-
dc.identifierhttp://dx.doi.org/10.1166/jbn.2014.1890-
dc.identifier.citationJournal Of Biomedical Nanotechnology. Valencia: Amer Scientific Publishers, v. 10, n. 9, p. 2218-2243, 2014.-
dc.identifier.issn1550-7033-
dc.identifier.urihttp://hdl.handle.net/11449/117285-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/117285-
dc.description.abstractWomen frequently develop disorders related to the vaginal area, including problems with the immune system, hygiene, genetic aspects and sexually transmitted diseases. Compared with other mucosal application sites, the vagina represents local effect as well as systemic drug delivery and is able to avoid the first-pass effect due to its large surface area, high blood supply and permeability to many active ingredients. It has been widely proposed that the use of drugs to treat vaginal disorders be combined with nanotechnology because nanosystems often potentiate the action of most active constituents, reducing the required dosage and side effects and improving the resulting activity in comparison with conventional treatments. Following the trend of using drug delivery systems based on nanotechology, many studies have encouraged the scientific community to turn to the development of new strategies for the vaginal administration of drugs. This study proposes to review the most common nanotechnology-based drug delivery systems that have been used to improve the effectiveness of active compounds administrated to treat vaginal disorders.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipPADC/FCF-UNESP (Araraquara, Brazil)-
dc.format.extent2218-2243-
dc.language.isoeng-
dc.publisherAmer Scientific Publishers-
dc.sourceWeb of Science-
dc.subjectNanotechnologyen
dc.subjectVaginal Disordersen
dc.subjectDrug Delivery Systemsen
dc.subjectVaginal Administrationen
dc.subjectNanoformulationsen
dc.titleNanotechnological Strategies for Vaginal Administration of Drugs-A Reviewen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationSao Paulo State Univ, Postgrad Program Pharmaceut Sci, Sch Pharmaceut, Dept Drugs & Med, BR-14801902 Sao Paulo, SP, Brazil-
dc.description.affiliationSao Paulo State Univ, Postgrad Program Pharmaceut Sci, Sch Pharmaceut, Dept Biol Sci, BR-14801902 Sao Paulo, SP, Brazil-
dc.description.affiliationUnespSao Paulo State Univ, Postgrad Program Pharmaceut Sci, Sch Pharmaceut, Dept Drugs & Med, BR-14801902 Sao Paulo, SP, Brazil-
dc.description.affiliationUnespSao Paulo State Univ, Postgrad Program Pharmaceut Sci, Sch Pharmaceut, Dept Biol Sci, BR-14801902 Sao Paulo, SP, Brazil-
dc.identifier.doi10.1166/jbn.2014.1890-
dc.identifier.wosWOS:000339430600023-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal Of Biomedical Nanotechnology-
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