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dc.contributor.authorBarbi, Mariana da Silva-
dc.contributor.authorCarvalho, Flavia Chiva-
dc.contributor.authorKiill, Charlene Priscila-
dc.contributor.authorBarud, Hernane da Silva-
dc.contributor.authorSantagneli, Silvia Helena-
dc.contributor.authorLima Ribeiro, Sidney Jose-
dc.contributor.authorGremião, Maria Palmira Daflon-
dc.identifier.citationJournal Of Nanoscience And Nanotechnology. Valencia: Amer Scientific Publishers, v. 15, n. 1, p. 865-874, 2015.-
dc.description.abstractZidovudine (AZT) is the antiretroviral drug most frequently used for the treatment of Acquired Immunodeficiency Syndrome. Its low oral bioavailability demands the development of innovative strategies to overcome the first pass metabolism. The nasal route is an option for enhanced therapeutic efficacy and to reduce the extent of the first-pass effect. In this article, AZT loaded chitosan nanoparticles were prepared by a modified ionotropic gelation method with sodium tripolyphosphate. The increase proportion of CS (NP1 10:01 (w/w)) promoted the formation of smaller nanoparticles (260 nm), while raising the proportion of TPP (NP2 5:1 w/w) increased the nanoparticles size (330 nm). The incorporation of AZT increased the nanoparticles size for both AZT-loaded nanoparticles AZT-loaded NP1 (406 nm) and AZT-loaded NP2 (425 nm). The incorporation of AZT into NP1 did not change the electrophoretic mobility, however, in AZT-loaded NP2 there was a significant increase. The positive surface of the nanoparticles is very important for the mucoadhesive properties due interaction with the sialic groups of the mucin. Nuclear resonance magnetic data showed that the higher concentration of chitosan in the nanoparticles favored the interaction of few phosphate units (pyrophosphate) by ionic interaction Scanning electron microscopy, revealed that the nanoparticles are nearly spherical shape with porous surface. The entrapment efficiency of AZT, was 17.58%+/- 1.48 and 11.02%+/- 2.05 for NP1 and NP2, respectively. The measurement of the mucoadhesion force using mucin discs and nasal tissue obtained values of NP1 = 2.12 and NP2 = 4.62. In vitro permeation study showed that the nanoparticles promoted an increase in the flux of the drug through the nasal mucosa. In view of these results, chitosan nanoparticles were found to be a promising approach for the incorporation of hydrophilic drugs and these results suggest that the CS-containing nanoparticles have great potential for nasal AZT administration.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.publisherAmer Scientific Publishers-
dc.sourceWeb of Science-
dc.subjectSystem for Drug Deliveryen
dc.titlePreparation and Characterization of Chitosan Nanoparticles for Zidovudine Nasal Deliveryen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUNESP Univ Estadual Paulista, Paulista State Univ, Sch Pharmaceut Sci, Fac Ciencias Farmaceut,Lab Farmacos & Medicamento, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUNESP Univ Estadual Paulista, Inst Quim, BR-14800900 Araraquara, SP, Brazil-
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Paulista State Univ, Sch Pharmaceut Sci, Fac Ciencias Farmaceut,Lab Farmacos & Medicamento, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Inst Quim, BR-14800900 Araraquara, SP, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal Of Nanoscience And Nanotechnology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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