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dc.contributor.authorAlbuquerque, M. T. P.-
dc.contributor.authorValera, M. C.-
dc.contributor.authorNakashima, M.-
dc.contributor.authorNor, J. E.-
dc.contributor.authorBottino, M. C.-
dc.identifier.citationJournal Of Dental Research. Thousand Oaks: Sage Publications Inc, v. 93, n. 12, p. 1222-1231, 2014.-
dc.description.abstractStemming from in vitro and in vivo pre-clinical and human models, tissue-engineering-based strategies continue to demonstrate great potential for the regeneration of the pulp-dentin complex, particularly in necrotic, immature permanent teeth. Nanofibrous scaffolds, which closely resemble the native extracellular matrix, have been successfully synthesized by various techniques, including but not limited to electrospinning. A common goal in scaffold synthesis has been the notion of promoting cell guidance through the careful design and use of a collection of biochemical and physical cues capable of governing and stimulating specific events at the cellular and tissue levels. The latest advances in processing technologies allow for the fabrication of scaffolds where selected bioactive molecules can be delivered locally, thus increasing the possibilities for clinical success. Though electrospun scaffolds have not yet been tested in vivo in either human or animal pulpless models in immature permanent teeth, recent studies have highlighted their regenerative potential both from an in vitro and in vivo (i.e., subcutaneous model) standpoint. Possible applications for these bioactive scaffolds continue to evolve, with significant prospects related to the regeneration of both dentin and pulp tissue and, more recently, to root canal disinfection. Nonetheless, no single implantable scaffold can consistently guide the coordinated growth and development of the multiple tissue types involved in the functional regeneration of the pulp-dentin complex. The purpose of this review is to provide a comprehensive perspective on the latest discoveries related to the use of scaffolds and/or stem cells in regenerative endodontics. The authors focused this review on bioactive nanofibrous scaffolds, injectable scaffolds and stem cells, and pre-clinical findings using stem-cell-based strategies. These topics are discussed in detail in an attempt to provide future direction and to shed light on their potential translation to clinical settings.en
dc.description.sponsorshipAmerican Association of Endodontists Foundation-
dc.description.sponsorshipNational Institutes of Health (NIH)/National Institute of Dental and Craniofacial Research (NIDCR)-
dc.description.sponsorshipIndiana University Purdue University (IUPUI/OVCR)-
dc.description.sponsorshipMinistry of Health, Labour and Welfare-
dc.description.sponsorshipbudget for promoting science and technology in Japan-
dc.publisherSage Publications Inc-
dc.sourceWeb of Science-
dc.subjecttissue scaffoldsen
dc.subjectdental pulpen
dc.subjectstem cellsen
dc.titleTissue-engineering-based Strategies for Regenerative Endodonticsen
dc.contributor.institutionIndiana Univ-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionNatl Ctr Geriatr & Gerontol-
dc.contributor.institutionUniv Michigan-
dc.description.affiliationIndiana Univ, Sch Dent, Div Dent Biomat, Dept Restorat Dent, Indianapolis, IN 46202 USA-
dc.description.affiliationUniv Estadual Paulista, Sao Jose dos Campos Dent Sch, Dept Restorat Dent, BR-12245000 Sao Paulo, Brazil-
dc.description.affiliationNatl Ctr Geriatr & Gerontol, Res Inst, Ctr Adv Med Dent & Oral Dis, Dept Dent Regenerat Med, Obu, Aichi 4748511, Japan-
dc.description.affiliationUniv Michigan, Sch Dent, Dept Cariol Restorat Sci & Endodont, Ann Arbor, MI 48109 USA-
dc.description.affiliationUnespUniv Estadual Paulista, Sao Jose dos Campos Dent Sch, Dept Restorat Dent, BR-12245000 Sao Paulo, Brazil-
dc.description.sponsorshipIdNational Institutes of Health (NIH)/National Institute of Dental and Craniofacial Research (NIDCR)DE023552-
dc.description.sponsorshipIdMinistry of Health, Labour and Welfare23-10-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal Of Dental Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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