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DC Field | Value | Language |
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dc.contributor.author | Spencer, P. | - |
dc.contributor.author | Ye, Q. | - |
dc.contributor.author | Misra, A. | - |
dc.contributor.author | Gonçalves, Sérgio Eduardo de Paiva | - |
dc.contributor.author | Laurence, J. S. | - |
dc.date.accessioned | 2015-03-18T15:55:46Z | - |
dc.date.accessioned | 2016-10-25T20:35:01Z | - |
dc.date.available | 2015-03-18T15:55:46Z | - |
dc.date.available | 2016-10-25T20:35:01Z | - |
dc.date.issued | 2014-12-01 | - |
dc.identifier | http://dx.doi.org/10.1177/0022034514550039 | - |
dc.identifier.citation | Journal Of Dental Research. Thousand Oaks: Sage Publications Inc, v. 93, n. 12, p. 1243-1249, 2014. | - |
dc.identifier.issn | 0022-0345 | - |
dc.identifier.uri | http://hdl.handle.net/11449/117299 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/117299 | - |
dc.description.abstract | In the United States, composites accounted for nearly 70% of the 173.2 million composite and amalgam restorations placed in 2006 (Kingman et al., 2012), and it is likely that the use of composite will continue to increase as dentists phase out dental amalgam. This trend is not, however, without consequences. The failure rate of composite restorations is double that of amalgam (Ferracane, 2013). Composite restorations accumulate more biofilm, experience more secondary decay, and require more frequent replacement. In vivo biodegradation of the adhesive bond at the composite-tooth interface is a major contributor to the cascade of events leading to restoration failure. Binding by proteins, particularly gp340, from the salivary pellicle leads to biofilm attachment, which accelerates degradation of the interfacial bond and demineralization of the tooth by recruiting the pioneer bacterium Streptococcus mutans to the surface. Bacterial production of lactic acid lowers the pH of the oral microenvironment, erodes hydroxyapatite in enamel and dentin, and promotes hydrolysis of the adhesive. Secreted esterases further hydrolyze the adhesive polymer, exposing the soft underlying collagenous dentinal matrix and allowing further infiltration by the pathogenic biofilm. Manifold approaches are being pursued to increase the longevity of composite dental restorations based on the major contributing factors responsible for degradation. The key material and biological components and the interactions involved in the destructive processes, including recent advances in understanding the structural and molecular basis of biofilm recruitment, are described in this review. Innovative strategies to mitigate these pathogenic effects and slow deterioration are discussed. | en |
dc.description.sponsorship | National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland | - |
dc.format.extent | 1243-1249 | - |
dc.language.iso | eng | - |
dc.publisher | Sage Publications Inc | - |
dc.source | Web of Science | - |
dc.subject | dentin bonding agents | en |
dc.subject | methacrylate | en |
dc.subject | gp340 | en |
dc.subject | Streptococcus mutans | en |
dc.subject | esterases | en |
dc.subject | biofilm | en |
dc.title | Proteins, Pathogens, and Failure at the Composite-Tooth Interface | en |
dc.type | outro | - |
dc.contributor.institution | Univ Kansas | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Univ Kansas, Dept Mech Engn, Lawrence, KS 66045 USA | - |
dc.description.affiliation | Univ Kansas, Bioengn Res Ctr, Lawrence, KS 66045 USA | - |
dc.description.affiliation | Univ Kansas, Dept Civil Engn, Lawrence, KS 66045 USA | - |
dc.description.affiliation | Univ Estadual Paulista, UNESP, Sch Dent Sao Jose dos Campos, Sao Jose Dos Campos, SP, Brazil | - |
dc.description.affiliation | Univ Kansas, Dept Pharmaceut Chem, Lawrence, KS 66045 USA | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, UNESP, Sch Dent Sao Jose dos Campos, Sao Jose Dos Campos, SP, Brazil | - |
dc.description.sponsorshipId | National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MarylandR01DE14392 | - |
dc.description.sponsorshipId | National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MarylandR01DE14392-08S1 | - |
dc.description.sponsorshipId | National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MarylandR01DE022054 | - |
dc.identifier.doi | 10.1177/0022034514550039 | - |
dc.identifier.wos | WOS:000345340400009 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Journal Of Dental Research | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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