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dc.contributor.authorSpencer, P.-
dc.contributor.authorYe, Q.-
dc.contributor.authorMisra, A.-
dc.contributor.authorGonçalves, Sérgio Eduardo de Paiva-
dc.contributor.authorLaurence, J. S.-
dc.date.accessioned2015-03-18T15:55:46Z-
dc.date.accessioned2016-10-25T20:35:01Z-
dc.date.available2015-03-18T15:55:46Z-
dc.date.available2016-10-25T20:35:01Z-
dc.date.issued2014-12-01-
dc.identifierhttp://dx.doi.org/10.1177/0022034514550039-
dc.identifier.citationJournal Of Dental Research. Thousand Oaks: Sage Publications Inc, v. 93, n. 12, p. 1243-1249, 2014.-
dc.identifier.issn0022-0345-
dc.identifier.urihttp://hdl.handle.net/11449/117299-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/117299-
dc.description.abstractIn the United States, composites accounted for nearly 70% of the 173.2 million composite and amalgam restorations placed in 2006 (Kingman et al., 2012), and it is likely that the use of composite will continue to increase as dentists phase out dental amalgam. This trend is not, however, without consequences. The failure rate of composite restorations is double that of amalgam (Ferracane, 2013). Composite restorations accumulate more biofilm, experience more secondary decay, and require more frequent replacement. In vivo biodegradation of the adhesive bond at the composite-tooth interface is a major contributor to the cascade of events leading to restoration failure. Binding by proteins, particularly gp340, from the salivary pellicle leads to biofilm attachment, which accelerates degradation of the interfacial bond and demineralization of the tooth by recruiting the pioneer bacterium Streptococcus mutans to the surface. Bacterial production of lactic acid lowers the pH of the oral microenvironment, erodes hydroxyapatite in enamel and dentin, and promotes hydrolysis of the adhesive. Secreted esterases further hydrolyze the adhesive polymer, exposing the soft underlying collagenous dentinal matrix and allowing further infiltration by the pathogenic biofilm. Manifold approaches are being pursued to increase the longevity of composite dental restorations based on the major contributing factors responsible for degradation. The key material and biological components and the interactions involved in the destructive processes, including recent advances in understanding the structural and molecular basis of biofilm recruitment, are described in this review. Innovative strategies to mitigate these pathogenic effects and slow deterioration are discussed.en
dc.description.sponsorshipNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland-
dc.format.extent1243-1249-
dc.language.isoeng-
dc.publisherSage Publications Inc-
dc.sourceWeb of Science-
dc.subjectdentin bonding agentsen
dc.subjectmethacrylateen
dc.subjectgp340en
dc.subjectStreptococcus mutansen
dc.subjectesterasesen
dc.subjectbiofilmen
dc.titleProteins, Pathogens, and Failure at the Composite-Tooth Interfaceen
dc.typeoutro-
dc.contributor.institutionUniv Kansas-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Kansas, Dept Mech Engn, Lawrence, KS 66045 USA-
dc.description.affiliationUniv Kansas, Bioengn Res Ctr, Lawrence, KS 66045 USA-
dc.description.affiliationUniv Kansas, Dept Civil Engn, Lawrence, KS 66045 USA-
dc.description.affiliationUniv Estadual Paulista, UNESP, Sch Dent Sao Jose dos Campos, Sao Jose Dos Campos, SP, Brazil-
dc.description.affiliationUniv Kansas, Dept Pharmaceut Chem, Lawrence, KS 66045 USA-
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Sch Dent Sao Jose dos Campos, Sao Jose Dos Campos, SP, Brazil-
dc.description.sponsorshipIdNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MarylandR01DE14392-
dc.description.sponsorshipIdNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MarylandR01DE14392-08S1-
dc.description.sponsorshipIdNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MarylandR01DE022054-
dc.identifier.doi10.1177/0022034514550039-
dc.identifier.wosWOS:000345340400009-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal Of Dental Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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