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dc.contributor.authorSpada, Ana Paula Machado-
dc.contributor.authorDamasceno, Debora Cristina-
dc.contributor.authorSinzato, Yuri Karen-
dc.contributor.authorCampos, Kleber Eduardo de-
dc.contributor.authorFaria, Priscila Afonso-
dc.contributor.authorDallaqua, Bruna-
dc.contributor.authorCalderon, Iracema de Mattos Paranhos-
dc.contributor.authorRudge, Marilza Vieira Cunha-
dc.contributor.authorRodrigues, Tiago-
dc.identifier.citationReproductive Sciences. Thousand Oaks: Sage Publications Inc, v. 21, n. 8, p. 973-977, 2014.-
dc.description.abstractThe aim of the present study was at evaluating the effects of oxidative stress in blood and placenta of mild diabetic Wistar rats. At birth, Wistar rats received citrate buffer (nondiabetic group, n = 15) and another group received streptozotocin (100 mg/kg, subcutaneous) to induce mild diabetes (diabetic, n = 15). The glycemia of these pregnant adult female rats were evaluated at days 0, 7, 14, and 21 of pregnancy, and at term pregnancy, the blood and placental samples were collected for oxidative stress measurements. The mild diabetes caused glycemia superior to 120 mg/dL during pregnancy, increased superoxide dismutase, glutathione peroxidase, glutathione reductase activities, and malondialdehyde levels in the blood, and catalase activity in the placenta. Thus, mild diabetes increased activities of antioxidant substances aiming at defending against the exacerbated oxidative stress but were not enough. The placenta also answered to diabetic milieu and increased antioxidant defense, showing that even a mild hyperglycemia was enough to cause placental and maternal blood changes.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.publisherSage Publications Inc-
dc.sourceWeb of Science-
dc.subjectoxidative stressen
dc.titleOxidative Stress in Maternal Blood and Placenta From Mild Diabetic Ratsen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionMato Grosso Fed Univ UFMT-
dc.contributor.institutionUniversidade Federal do ABC (UFABC)-
dc.description.affiliationUNESP Univ Estadual Paulista, Lab Expt Res Gynecol & Obstet, Botucatu Med Sch, Grad Program Gynecol Obstet & Mastol, Botucatu, SP, Brazil-
dc.description.affiliationMato Grosso Fed Univ UFMT, Univ Ctr Araguaia, Inst Biol & Hlth Sci, Barra Do Garcas, Mato Grosso, Brazil-
dc.description.affiliationUFABC, Sao Paulo, Brazil-
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Lab Expt Res Gynecol & Obstet, Botucatu Med Sch, Grad Program Gynecol Obstet & Mastol, Botucatu, SP, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofReproductive Sciences-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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