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dc.contributor.authorMokry, Fabiana Barichello-
dc.contributor.authorBuzanskas, Marcos Eli-
dc.contributor.authorMudadu, Mauricio de Alvarenga-
dc.contributor.authorGrossi, Daniela do Amaral-
dc.contributor.authorHiga, Roberto Hiroshi-
dc.contributor.authorVentura, Ricardo Vieira-
dc.contributor.authorLima, Andressa Oliveira de-
dc.contributor.authorSargolzaei, Mehdi-
dc.contributor.authorConceicao Meirelles, Sarah Laguna-
dc.contributor.authorSchenkel, Flavio Schramm-
dc.contributor.authorGualberto Barbosa da Silva, Marcos Vinicius-
dc.contributor.authorMeo Niciura, Simone Cristina-
dc.contributor.authorAlencar, Mauricio Mello de-
dc.contributor.authorMunari, Danisio Prado-
dc.contributor.authorAlmeida Regitano, Luciana Correia de-
dc.identifier.citationBmc Genomics. London: Biomed Central Ltd, v. 15, 9 p., 2014.-
dc.description.abstractBackground: The development of linkage disequilibrium (LD) maps and the characterization of haplotype block structure at the population level are useful parameters for guiding genome wide association (GWA) studies, and for understanding the nature of non-linear association between phenotypes and genes. The elucidation of haplotype block structure can reduce the information of several single nucleotide polymorphisms (SNP) into the information of a haplotype block, reducing the number of SNPs in a coherent way for consideration in GWA and genomic selection studies.Results: The maximum average LD, measured by r(2) varied between 0.33 to 0.40 at a distance of < 2.5 kb, and the minimum average values of r(2) varied between 0.05 to 0.07 at distances ranging from 400 to 500 kb, clearly showing that the average r(2) reduced with the increase in SNP pair distances. The persistence of LD phase showed higher values at shorter genomic distances, decreasing with the increase in physical distance, varying from 0.96 at a distance of < 2.5 kb to 0.66 at a distance from 400 to 500 kb. A total of 78% of all SNPs were clustered into haplotype blocks, covering 1,57 Mb of the total autosomal genome size.Conclusions: This study presented the first high density linkage disequilibrium map and haplotype block structure for a composite beef cattle population, and indicates that the high density SNP panel over 700 k can be used for genomic selection implementation and GWA studies for Canchim beef cattle.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipEmbrapa (Brazilian Agricultural Research Corporation)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.publisherBiomed Central Ltd-
dc.sourceWeb of Science-
dc.titleLinkage disequilibrium and haplotype block structure in a composite beef cattle breeden
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)-
dc.contributor.institutionUniv Guelph-
dc.contributor.institutionUniversidade Federal de Lavras (UFLA)-
dc.description.affiliationUniv Fed Sao Carlos, Dept Genet & Evolut, BR-13565905 Sao Carlos, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Agr & Vet, Dept Ciencias Exatas, BR-14884900 Jaboticabal, SP, Brazil-
dc.description.affiliationEmbrapa Southeast Livestock, BR-13560970 Sao Carlos, SP, Brazil-
dc.description.affiliationUniv Guelph, Ctr Genet Improvement Livestock, Guelph, ON N1G 2W1, Canada-
dc.description.affiliationEmbrapa Agr Informat, BR-13083886 Campinas, SP, Brazil-
dc.description.affiliationUniv Fed Lavras, Dept Anim Sci, BR-3720000 Lavras, Brazil-
dc.description.affiliationEmbrapa Dairy Cattle, BR-36038330 Juiz De Fora, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Agr & Vet, Dept Ciencias Exatas, BR-14884900 Jaboticabal, SP, Brazil-
dc.description.sponsorshipIdCAPES: 02663/09-0-
dc.description.sponsorshipIdCNPq: 142053/2010-4-
dc.description.sponsorshipIdCAPES: 5285-11-9-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofBmc Genomics-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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