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dc.contributor.authorMoreno, Mayara Franzoi-
dc.contributor.authorDe Laquila, Rachel-
dc.contributor.authorOkuda, Marcos Hiromu-
dc.contributor.authorLira, Fabio Santos-
dc.contributor.authorMorais Honorato de Souza, Gabriel Inacio de-
dc.contributor.authorSouza, Claudio Teodoro de-
dc.contributor.authorTelles, Monica Marques-
dc.contributor.authorRibeiro, Eliane Beraldi-
dc.contributor.authorOller do Nascimento, Claudia Maria-
dc.contributor.authorOyama, Lila Missae-
dc.identifier.citationDiabetology & Metabolic Syndrome. London: Biomed Central Ltd, v. 6, 7 p., 2014.-
dc.description.abstractBackground: Obesity is associated with increased adipose tissue and glucose intolerance. High-fat diets (HFDs) are known to induce obesity and increase proinflammatory adipokines. The consumption of green tea may improve the health of obese individuals because it contains a potent antioxidant that has effects on body weight, energy expenditure and serum cholesterol concentrations.Methods: We examined the effects of epigallocatechin-3-gallate (EGCG) (50 mg/kg body weight per day) or saline after 30 or 60 days of treatment. Mice were distributed into four groups: 1) NS: normolipidic diet receiving saline; 2) NE: normolipidic diet receiving EGCG; 3) HFS: high-fat diet receiving saline; 4) HFE: high-fat diet receiving EGCG.Results: We observed that administration of a HFD plus EGCG treatment for 60 days reduced delta weight, the relative weights of the mesenteric adipose tissue (MES), retroperitonial adipose tissue (RET), epididymal adipose tissue (EPI), the sum of the adipose tissues (SAT), reduced triacylglycerol (TG) and improved both high-density lipoprotein (HDL) cholesterol levels and the adiponectin/STA ratio when compared with HFS.Conclusions: Our results suggest that the chronic administration of EGCG (60 days) promoted a significant improvement in glucose tolerance, decreased adipose tissue deposits, weight mass, TG and HDL-C only when associated with high-fat diet treatment.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.publisherBiomed Central Ltd-
dc.sourceWeb of Science-
dc.subjectHigh-fat dieten
dc.subjectAdipose tissueen
dc.titleMetabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed miceen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)-
dc.contributor.institutionFac Integradas Coracao Jesus FAINC-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniv Southern Santa Catarina-
dc.description.affiliationUniv Fed Sao Paulo, EPM, Dept Fisiol, Sao Paulo, Brazil-
dc.description.affiliationFac Integradas Coracao Jesus FAINC, Santo Andre, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista, UNESP, Dept Phys Educ, Immunometab Res Grp, Presidente Prudente, SP, Brazil-
dc.description.affiliationUniv Southern Santa Catarina, Hlth Sci Unit, Lab Exercise Biochem & Physiol, Criciuma, SC, Brazil-
dc.description.affiliationUniv Fed Sao Paulo, Dept Ciencias Biol, Diadema, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Dept Phys Educ, Immunometab Res Grp, Presidente Prudente, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 09/14373-8-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofDiabetology & Metabolic Syndrome-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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