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dc.contributor.authorAraujo-Souza, Patricia S. de-
dc.contributor.authorRamanakumar, Agnihotram V.-
dc.contributor.authorCandeias, Joao M. G.-
dc.contributor.authorThomann, Patricia-
dc.contributor.authorTrevisan, Andrea-
dc.contributor.authorFranco, Eduardo L.-
dc.contributor.authorVilla, Luisa L.-
dc.contributor.authorLudwig-McGill Cohort Study-
dc.identifier.citationBmc Infectious Diseases. London: Biomed Central Ltd, v. 14, 9 p., 2014.-
dc.description.abstractBackground: Immunity plays an important role in controlling human papillomavirus (HPV) infection and associated lesions. Unlike infections caused by other viruses, natural HPV infection does not always result in a protective antibody response. Therefore, HPV antibodies are also considered markers of cumulative exposure. The aim of this study was to identify determinants of HPV16 seroreactivity at enrollment among women from the Ludwig-McGill cohort, a natural history study of HPV infection and risk of cervical neoplasia.Methods: HPV16 serology was assessed by ELISA for L1 and L2 capsid antigens, while HPV typing and viral load measurements were performed by PCR-based methods. The associations were analyzed by unconditional logistic regression.Results: Of 2049 subjects, 425 (20.7%) were strongly seropositive for HPV16. In multivariate analysis, seroreactivity was positively correlated with age, lifetime number of sexual partners, frequency of sex, and HPV16 viral load, and negatively associated with duration of smoking.Conclusions: HPV16 seroreactivity is determined by factors that reflect viral exposure.en
dc.description.sponsorshipLudwig Institute for Cancer Research-
dc.description.sponsorshipU.S. National Cancer Institute-
dc.description.sponsorshipCanadian Institutes of Health Research-
dc.publisherBiomed Central Ltd-
dc.sourceWeb of Science-
dc.subjectNatural antibodiesen
dc.subjectHPV16 seropositivityen
dc.titleDeterminants of baseline seroreactivity to human papillomavirus type 16 in the Ludwig-McGill cohort studyen
dc.contributor.institutionLudwig Inst Canc Res-
dc.contributor.institutionUniversidade Federal Fluminense (UFF)-
dc.contributor.institutionBrazilian Natl Canc Inst-
dc.contributor.institutionMcGill Univ-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionInst Gynaecol Canc Res-
dc.contributor.institutionUniv Montreal-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionSanta Casa Sao Paulo-
dc.description.affiliationLudwig Inst Canc Res, Sao Paulo, Brazil-
dc.description.affiliationUniv Fed Fluminense, Dept Immunobiol, Niteroi, RJ, Brazil-
dc.description.affiliationBrazilian Natl Canc Inst, Program Cellular Biol, Rio De Janeiro, Brazil-
dc.description.affiliationMcGill Univ, Dept Oncol, Montreal, PQ, Canada-
dc.description.affiliationUniv Estadual Paulista, Inst Biosci, Dept Microbiol & Immunol, Botucatu, SP, Brazil-
dc.description.affiliationInst Gynaecol Canc Res, Sao Paulo, Brazil-
dc.description.affiliationUniv Montreal, CHUM, Div Gynecol Oncol, Montreal, PQ, Canada-
dc.description.affiliationMcGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada-
dc.description.affiliationICESP, Sao Paulo Canc Inst, Mol Biol Lab, Sao Paulo, Brazil-
dc.description.affiliationUniv Sao Paulo, Sch Med, Dept Radiol & Oncol, Sao Paulo, Brazil-
dc.description.affiliationUniv Sao Paulo, Sch Med, Sao Paulo, Brazil-
dc.description.affiliationSanta Casa Sao Paulo, Sao Paulo, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biosci, Dept Microbiol & Immunol, Botucatu, SP, Brazil-
dc.description.sponsorshipIdU.S. National Cancer InstituteCA70269-
dc.description.sponsorshipIdCanadian Institutes of Health Research49396-
dc.description.sponsorshipIdCanadian Institutes of Health Research83320-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofBmc Infectious Diseases-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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