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dc.contributor.authorSabino, Flavia Cal-
dc.contributor.authorRibeiro, Amanda Oliveira-
dc.contributor.authorTufik, Sergio-
dc.contributor.authorTorres, Laila Brito-
dc.contributor.authorOliveira, José Américo de-
dc.contributor.authorAraujo Moraes Mello, Luiz Eugenio-
dc.contributor.authorCavalcante, Jeferson Souza-
dc.contributor.authorPedrazzoli, Mario-
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 9, n. 9, 6 p., 2014.-
dc.description.abstractThe PER3 gene is one of the clock genes, which function in the core mammalian molecular circadian system. A variable number of tandem repeats (VNTR) locus in the 18th exon of this gene has been strongly associated to circadian rhythm phenotypes and sleep organization in humans, but it has not been identified in other mammals except primates. To better understand the evolution and the placement of the PER3 VNTR in a phylogenetical context, the present study enlarges the investigation about the presence and the structure of this variable region in a large sample of primate species and other mammals. The analysis of the results has revealed that the PER3 VNTR occurs exclusively in simiiforme primates and that the number of copies of the primitive unit ranges from 2 to 11 across different primate species. Two transposable elements surrounding the 18th exon of PER3 were found in primates with published genome sequences, including the tarsiiforme Tarsius syrichta, which lacks the VNTR. These results suggest that this VNTR may have evolved in a common ancestor of the simiiforme branch and that the evolutionary copy number differentiation of this VNTR may be associated with primate simiiformes sleep and circadian phenotype patterns.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipassociation incentive fund psychopharmacology (AFIP)-
dc.description.sponsorshipcenter for research innovation and diffusion (CEPID)-
dc.publisherPublic Library Science-
dc.sourceWeb of Science-
dc.titleEvolutionary History of the PER3 Variable Number of Tandem Repeats (VNTR): Idiosyncratic Aspect of Primate Molecular Circadian Clocken
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)-
dc.contributor.institutionPrimate Natl Ctr IEC CENP-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniv Fed Rio Grande do Norte-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, Brazil-
dc.description.affiliationUniv Fed Sao Paulo, Dept Genet & Evolutionary Biol, Sao Paulo, Brazil-
dc.description.affiliationPrimate Natl Ctr IEC CENP, Brazilian Minist Hlth, Hlth Surveillance Secretariat, Ananindeua, Para, Brazil-
dc.description.affiliationSao Paulo State Univ, Aracatuba Dent Sch, Dept Basic Sci, Div Anat, Aracatuba, Brazil-
dc.description.affiliationUniv Fed Sao Paulo, Dept Physiol, Sao Paulo, Brazil-
dc.description.affiliationUniv Fed Rio Grande do Norte, Lab Neurochem Studies, BR-59072970 Natal, RN, Brazil-
dc.description.affiliationUniv Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo, Brazil-
dc.description.affiliationUnespSao Paulo State Univ, Aracatuba Dent Sch, Dept Basic Sci, Div Anat, Aracatuba, Brazil-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofPlos One-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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