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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/117417
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dc.contributor.authorSantos, Priscila P.-
dc.contributor.authorOliveira, Fernando-
dc.contributor.authorFerreira, Vanessa C. M. P.-
dc.contributor.authorPolegato, Bertha Furlan-
dc.contributor.authorRoscani, Meliza Goi-
dc.contributor.authorFernandes, Ana Angelica-
dc.contributor.authorModesto, Pamela-
dc.contributor.authorRafacho, Bruna P. M.-
dc.contributor.authorZanati, Silmeia G.-
dc.contributor.authorDi Lorenzo, Annarita-
dc.contributor.authorMatsubara, Luiz Shiguero-
dc.contributor.authorPaiva, Sergio Alberto Rupp de-
dc.contributor.authorZornoff, Leonardo Antonio Mamede-
dc.contributor.authorMinicucci, Marcos Ferreira-
dc.contributor.authorGaiolla, Paula Schmidt Azevedo-
dc.date.accessioned2015-03-18T15:56:05Z-
dc.date.accessioned2016-10-25T20:35:18Z-
dc.date.available2015-03-18T15:56:05Z-
dc.date.available2016-10-25T20:35:18Z-
dc.date.issued2014-12-02-
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0113739-
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 9, n. 12, 13 p., 2014.-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/11449/117417-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/117417-
dc.description.abstractBackground/Aims: Experimental and clinical studies have shown the direct toxic effects of cigarette smoke (CS) on the myocardium, independent of vascular effects. However, the underlying mechanisms are not well known.Methods: Wistar rats were allocated to control (C) and cigarette smoke (CS) groups. CS rats were exposed to cigarette smoke for 2 months.Results: After that morphometric, functional and biochemical parameters were measured. The echocardiographic study showed enlargement of the left atria, increase in the left ventricular systolic volume and reduced systolic function. Within the cardiac metabolism, exposure to CS decreased beta hydroxy acyl coenzyme A dehydrogenases and citrate synthases and increased lactate dehydrogenases. Peroxisome proliferator-activated receptor alpha (PPAR alpha) and peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) were expressed similarly in both groups. CS increased serum lipids and myocardial triacylglycerols (TGs). These data suggest that impairment in fatty acid oxidation and the accumulation of cardiac lipids characterize lipotoxicity. CS group exhibited increased oxidative stress and decreased antioxidant defense. Finally, the myocyte cross-sectional area and active Caspase 3 were increased in the CS group.Conclusion: The cardiac remodeling that was observed in the CS exposure model may be explained by abnormalities in energy metabolism, including lipotoxicity and oxidative stress.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipBotucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Sao Paulo, Brasil-
dc.format.extent13-
dc.language.isoeng-
dc.publisherPublic Library Science-
dc.sourceWeb of Science-
dc.titleThe Role of Lipotoxicity in Smoke Cardiomyopathyen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionCornell Univ-
dc.description.affiliationUNESP Univ Estadual Paulista, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil-
dc.description.affiliationUNESP Univ Estadual Paulista, Inst Biociencias Botucatu, Dept Chem & Biochem, Botucatu, SP, Brazil-
dc.description.affiliationCornell Univ, Weill Med Coll, Ctr Vasc Biol, Dept Pathol & Lab Med, New York, NY 10021 USA-
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil-
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Inst Biociencias Botucatu, Dept Chem & Biochem, Botucatu, SP, Brazil-
dc.identifier.doi10.1371/journal.pone.0113739-
dc.identifier.wosWOS:000345869700045-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileWOS000345869700045.pdf-
dc.relation.ispartofPlos One-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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